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MFGE8 /Lactadherin

milk fat globule-EGF factor 8 protein

Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization By similarity. Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. Binds specifically to rotavirus and inhibits its replication.

Gene Name:	milk fat globule-EGF factor 8 protein
Synonyms:	MFGE8, Breast epithelial antigen BA46, EDIL1, HP47, Lactadherin, Medin, MFGM, Milk fat globule-EGF factor 8, HsT19888, OAcGD3S, SPAG10, Sperm associated antigen 10, MFG-E8, SED1, Sperm surface protein hP47, BA46, HMFG
Target Sequences:	NM_005928 NP_005919.2 Q08431

Publications (2)

Effect of innate antiviral glycoproteins in breast milk on seroconversion to rotavirus vaccine (Rotarix) in children in Lusaka, Zambia. Mwila-Kazimbaya K, Garcia MP, Bosomprah S, Laban NM, Chisenga CC, Permar SR, Simuyandi M, Munsaka S, Chilengi R. PloS one. 2017 December;12:e0189351. [Full Text Article] [PubMed:29284036] [PMC:PMC5746212]

Restoration of Circulating MFGE8 (Milk Fat Globule-EGF Factor 8) Attenuates Cardiac Hypertrophy Through Inhibition of Akt Pathway. Deng KQ, Li J, She ZG, Gong J, Cheng WL, Gong FH, Zhu XY, Zhang Y, Wang Z, Li H. Hypertension. 2017 October;70:770-779. [Full Text Article] [PubMed:28827473]

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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