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Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo.Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.
Gene Name: | methionyl aminopeptidase 2 |
Family/Subfamily: | Exopeptidase , Metallopeptidase M24C |
Synonyms: | METAP2, MAP 2, MetAP 2, Methionyl aminopeptidase 2, Methionine aminopeptidase 2, Peptidase M 2, MNPEP, p67, EIF-2-associated p67 homolog, p67eIF2 |
Target Sequences: | NM_006838 NP_006829.1 P50579 |
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