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MEPE
matrix extracellular phosphoglycoprotein
MEPE is a secreted calcium-binding phosphoprotein that belongs to the small integrin-binding ligand, N-linked glycoprotein (SIBLING) family of proteins. Members of this family are components of the extracellular matrix of bone and dentin and regulate bone mineralization. Deficiency of a similar protein in mouse results in increased bone mass. Mice lacking this gene are resistant to aging-related trabecular bone loss. Alternative splicing results in multiple transcript variants.
| Gene Name: | matrix extracellular phosphoglycoprotein |
| Synonyms: | MEPE, Osteoblast/osteocyte factor 45, OF45 |
| Target Sequences: | NM_020203 NP_064588.1 Q9NQ76 |
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