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May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for breast carcinoma cell migration.
Gene Name: | mediator of cell motility 1 |
Synonyms: | MEMO1, C2orf4, Mediator of cell motility 1, MEMO, Protein MEMO1, NS5ATP7, C21orf19-like protein, CGI-27, Memo-1 |
Target Sequences: | NM_015955 NP_057039.1 Q9Y316 |
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