MELK

maternal embryonic leucine zipper kinase

Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis.

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Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

MELK (3)

Publications

No (3)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

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Human MELK Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80977

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

74.5 kDa

Price:

20 µg/$150

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Human MELK Protein (Recombinant GST, N-terminus) (aa550-650) - LS-G61259

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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MELK Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101259

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

74.5 kDa

Price:

100 µg/$494

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