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MED23 / SUR2

mediator complex subunit 23

Required for transcriptional activation subsequent to the assembly of the preinitiation complex (By similarity). Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling.

Gene Name: mediator complex subunit 23
Synonyms: MED23, CRSP133, CRSP130, CRSP complex subunit 3, DRIP130, HSur-2, KIAA1216, Protein sur-2 homolog, SUR2, MRT18, ARC130, SUR-2, CRSP3, Mediator complex subunit 23
Target Sequences: NM_004830 NP_004821.2 Q9ULK4

Publications (1)

1
The Mediator Subunit, Med23 Is Required for Embryonic Survival and Regulation of Canonical WNT Signaling During Cranial Ganglia Development. Soma Dash, Shachi Bhatt, Lisa L Sandell, Christopher W Seidel, Youngwook Ahn, Robb E Krumlauf, Paul A Trainor. Frontiers in physiology. 2020 November;11:531933. [Full Text Article] [PubMed:33192541] [PMC:PMC7642510] Related Antibodies: LS-C193128.

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Proteins (1)
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MED23 / SUR2 (1)
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GST, N-terminus (1)
Human (1)
Wheat Germ Extract (1)
MED23 / SUR2 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).