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Required for transcriptional activation subsequent to the assembly of the preinitiation complex (By similarity). Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling.
Gene Name: | mediator complex subunit 23 |
Synonyms: | MED23, CRSP133, CRSP130, CRSP complex subunit 3, DRIP130, HSur-2, KIAA1216, Protein sur-2 homolog, SUR2, MRT18, ARC130, SUR-2, CRSP3, Mediator complex subunit 23 |
Target Sequences: | NM_004830 NP_004821.2 Q9ULK4 |
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