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Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Gene Name: | mediator complex subunit 21 |
Synonyms: | MED21, HSrb7, RNAPII complex component SRB7, SRB7, SURB7, Mediator complex subunit 21 |
Target Sequences: | NM_004264 NP_004255.2 Q13503 |
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