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MED13 / TRAP240
mediator complex subunit 13
This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. The product of this gene is proposed to form a sub-complex with MED12, cyclin C, and CDK8 that can negatively regulate transactivation by mediator.
| Gene Name: | mediator complex subunit 13 |
| Synonyms: | MED13, KIAA0593, Mediator complex subunit 13, ARC250, THRAP1, DRIP250, HSPC221, TRAP240 |
| Target Sequences: | NM_005121 NP_005112.2 Q9UHV7 |
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