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MED1 / TRAP220

mediator complex subunit 1

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize.

Gene Name: mediator complex subunit 1
Synonyms: MED1, ARC205, CRSP1, DRIP205, DRIP230, Mediator complex subunit 1, PBP, PPARG binding protein, RB18A, TRIP-2, TRIP2, PPARBP, CRSP200, p53 regulatory protein RB18A, PPAR binding protein, PPAR-binding protein, PPARGBP, TR-interacting protein 2, TRAP220
Target Sequences: NM_004774 NP_004765.2 Q15648

Publications (1)

1
The onset of human ectopic pregnancy demonstrates a differential expression of miRNAs and their cognate targets in the Fallopian tube. Feng Y, Zou S, Weijdegård B, Chen J, Cong Q, Fernandez-Rodriguez J, Wang L, Billig H, Shao R. International journal of clinical and experimental pathology. 2014 7:64-79. (IHC; Human) [PubMed:24427327] [PMC:PMC3885461] Related Antibodies: LS-C119067.

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Proteins (5)
Over-Expression Lysate (2)
Recombinant (3)
MED1 / TRAP220 (5)
No (5)
6His-SUMO, N-terminus (1)
GST, N-terminus (1)
His-T7 (1)
Myc-DDK (Flag) (2)
Human (4)
293T Cells (1)
E. coli (2)
HEK 293 Cells (1)
Wheat Germ Extract (1)
Purified (1)
MED1 / TRAP220 Protein - Recombinant Mediator Complex Subunit 1 By SDS-PAGE
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E. coli
His-T7
27.5 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
MED1 / TRAP220 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
MED1 / TRAP220 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
168.3 kDa
100 µg/$710
MED1 / TRAP220 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
6His-SUMO, N-terminus
1 mg/$1,679; 100 µg/$500; 20 µg/$364
MED1 / TRAP220 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
168.3 kDa
20 µg/$215
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).