LSBio
Products
  • Antibodies
  • All Antibodies
  • Primary Antibodies
  • Secondary Antibodies
  • IHC-plus Antibodies
  • Isotype Control Antibodies
  • ELISA and Assay Kits
  • All Kits
  • Assay Kits
  • Traditional ELISA Kits
  • Cell-Based ELISA Kits
  • DNA-Binding ELISA Kits
  • Phospho-Specific ELISA Kits
  • ELISA Development Kits
  • Chemiluminescent CLIA Kits
  • Proteins
  • All Proteins
  • Recombinant Proteins
  • Native Proteins
  • Over-expression Lysates
  • Cell and Tissue Lysates
  • Bio-active Proteins
  • Animal-free Proteins
  • Synthetic Peptides
  • Biochemicals
  • All Biochemicals

  • Immunohistochemistry
  • Comprehensive IHC Reports
  • Custom IHC Services
  • TCR Screening Services
  • IHC-plus Antibodies
Services
  • Immunohistochemistry Services

  • Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

  • TCR Screening Services

  • Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Have a question? CustomerSupport@LSBio.com
Resources
  • Purchasing
  • Product Ordering Terms and Conditions
  • Holiday Schedule
  • About the LSBio Guarantee
  • About Our Rewards Program
  • Reference Material
  • About LSBio (LifeSpan BioSciences Inc.)
  • About Our 2-million Specimen Tissue Bank
  • About Our IHC Validation Process
  • About Our IHC-plus™ Immunohistochemistry Protocol
  • Protocols
  • Secure Logins
  • Login to Our Secure ShareFile Site
  • Login to Our IHC Database
Distributors
Contact Us

LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121

Phone: 866-819-4732 (Toll Free North America)
206-374-1102 (International)

Fax: 866-206-6909 (Toll Free North America)
206-577-4565 (International)
How to Buy - Details about how to buy our products.

Orders@LSBio.com - To submit a new order.

Customer.Support@LSBio.com - To submit questions about existing orders, pricing, availability, bulk quotes, proforma invoice requests, or other billing issues.

Technical.Support@LSBio.com - To request technical information requests about an LSBio product or its application.

Sales@LSBio.com - To request information about fee-for-service contract IHC studies, IHC reports, distribution agreements, or general business development.

Worldwide Distributors List - To find your local distributor if you're not within the United States.
Login ▾
Wish List
View Cart

MECP2

methyl CpG binding protein 2 (Rett syndrome)

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.

Gene Name: methyl CpG binding protein 2 (Rett syndrome)
Synonyms: MECP2, AUTSX3, Methyl-CpG-binding protein 2, MRX16, MRX79, MRXSL, RTT, RTS, MeCp-2 protein, RS, MRXS13, PPMX
Target Sequences: NM_004992 NP_004983.1 P51608

Publications (2)

1
The Rett syndrome protein MeCP2 regulates synaptic scaling. Qiu Z, Sylwestrak EL, Lieberman DN, Zhang Y, Liu XY, Ghosh A. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012 32:989-94. [PubMed:22262897]
2
DNA methylation and methyl-binding proteins control differential gene expression in distinct cortical areas of macaque monkey. Hata K, Mizukami H, Sadakane O, Watakabe A, Ohtsuka M, Takaji M, Kinoshita M, Isa T, Ozawa K, Yamamori T. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2013 Dec;33:19704-14. [Full Text Article] [PubMed:24336734] Related Antibodies: LS-C98528.

Filtered By: None
Target
mecp2 (93)
Reactivity
Human (87)
Mouse (46)
Rat (30)
Bat (13)
Bovine (9)
Chimpanzee (7)
Dog (9)
Gibbon (3)
Guinea pig (8)
Horse (13)
Monkey (14)
Non-Human Primate (1)
Pig (8)
Rabbit (8)
Application
IHC (20)
IHC-P (11)
WB (74)
Flo (22)
ChrIP (1)
DB (9)
ELISA (48)
ICC (3)
IF (4)
IP (1)
Host
rabbit (89)
mouse (3)
chicken (1)
Isotype
IgG (70)
IgG1 (1)
IgG2a,k (2)
Clonality
monoclonal mc (3)
polyclonal pc (90)
Clone
1B11 (1)
4B6 (1)
5H12 (1)
Format
AP Conjugated (8)
APC Conjugated (8)
Azide-free (6)
Biotin Conjugated (11)
FITC Conjugated (10)
HRP Conjugated (11)
PE Conjugated (8)
Unconjugated (37)
Epitope
N-Terminus (11)
pSer80 (9)
Ser421 (8)
aa3-33 (7)
pSer292 (7)
C-Terminus (6)
aa406-435 (6)
aa35-84 (4)
aa1-280 (1)
aa11-25 (1)
aa11-25,aa181-195 (1)
aa2-211 (1)
aa310-360 (1)
aa58-87 (1)
pSer421 (1)
Publications
No (92)
Yes (1)
Showing 1-25 out of 93 results
Anti-MECP2 Antibody (clone 4B6) IHC-plus™ LS-B5462

Mouse Monoclonal [clone 4B6] (IgG2a,k) to Human MECP2
Mouse, Rat, Human
ELISA IHC-P WB
Unconjugated
Anti-MECP2 Antibody (Ser421) LS-C98528

Rabbit Polyclonal to Human MECP2
Mouse, Human
WB
Unconjugated
Anti-MECP2 Antibody (N-Terminus) LS-C31934

Rabbit Polyclonal (IgG) to Human MECP2
Mouse, Rat, Horse, Bat, Human, Monkey
WB
Unconjugated
Anti-MECP2 Antibody LS-C355680

Rabbit Polyclonal (IgG) to Human MECP2
Mouse, Rat, Human, Monkey
ICC IF IHC-P IP WB
Unconjugated
Anti-MECP2 Antibody LS-C482483

Rabbit Polyclonal to Human MECP2
Mouse, Rat, Human
ICC IF IHC-P WB
Unconjugated
Anti-MECP2 Antibody LS-C334225

Rabbit Polyclonal (IgG) to Human MECP2
Mouse, Rat, Human
IF IHC WB
Unconjugated
Anti-MECP2 Antibody (N-Terminus) LS-C322929

Rabbit Polyclonal (IgG) to Human MECP2
Human
ELISA Flo IHC WB
Unconjugated
Anti-MECP2 Antibody (N-Terminus, Biotin) LS-C262921

Rabbit Polyclonal (IgG) to Human MECP2
Human
ELISA Flo IHC WB
Biotin Conjugated
Anti-MECP2 Antibody (N-Terminus, FITC) LS-C262923

Rabbit Polyclonal (IgG) to Human MECP2
Human
ELISA Flo IHC WB
FITC Conjugated
Anti-MECP2 Antibody (N-Terminus, Azide-free, HRP) LS-C262919

Rabbit Polyclonal (IgG) to Human MECP2
Human
ELISA Flo IHC WB
HRP Conjugated, Azide-free
Anti-MECP2 Antibody (N-Terminus, APC) LS-C262918

Rabbit Polyclonal (IgG) to Human MECP2
Human
ELISA Flo IHC WB
APC Conjugated
Anti-MECP2 Antibody (N-Terminus, AP) LS-C262917

Rabbit Polyclonal (IgG) to Human MECP2
Human
ELISA Flo IHC WB
AP Conjugated
Anti-MECP2 Antibody (N-Terminus, PE) LS-C262920

Rabbit Polyclonal (IgG) to Human MECP2
Human
ELISA Flo IHC WB
PE Conjugated
Anti-MECP2 Antibody (aa11-25) IHC-plus™ LS-B2054

Rabbit Polyclonal (IgG) to Human MECP2
Human
IHC-P WB
Unconjugated
Anti-MECP2 Antibody IHC-plus™ LS-B13236

Rabbit Polyclonal (IgG) to Human MECP2
Mouse, Dog, Bovine, Rat, Horse, Bat, Chimpanzee, Human, Monkey
IHC-P WB
Unconjugated
Anti-MECP2 Antibody (C-Terminus) IHC-plus™ LS-B11987

Rabbit Polyclonal to Human MECP2
Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Horse, Bat, Human, Monkey
IHC-P WB
Unconjugated
Anti-MECP2 Antibody LS-C109334

Rabbit Polyclonal to Human MECP2
Mouse, Human
ICC IF WB
Unconjugated
Anti-MECP2 Antibody LS-C405144

Rabbit Polyclonal (IgG) to Human MECP2
Mouse, Rat, Human
ELISA IHC WB
Unconjugated
Anti-MECP2 Antibody LS-C496688

Rabbit Polyclonal (IgG) to Human MECP2
Human
Flo IHC WB
Unconjugated
Anti-MECP2 Antibody (aa58-87) LS-C164113

Rabbit Polyclonal to Human MECP2
Human
Flo IHC-P WB
Unconjugated
Anti-MECP2 Antibody (aa3-33) LS-C322930

Rabbit Polyclonal (IgG) to Human MECP2
Human
ELISA Flo WB
Unconjugated
Anti-MECP2 Antibody (aa406-435) LS-C322933

Rabbit Polyclonal (IgG) to Human MECP2
Human
ELISA Flo WB
Unconjugated
Anti-MECP2 Antibody (aa2-211) LS-C178841

Rabbit Polyclonal to Human MECP2
Human
ELISA IHC WB
Unconjugated
Anti-MECP2 Antibody (clone 1B11) LS-C133311

Mouse Monoclonal [clone 1B11] (IgG2a,k) to Human MECP2
Human
ELISA WB
Unconjugated
Anti-MECP2 Antibody (phospho-Ser292) LS-C327867

Rabbit Polyclonal (IgG) to Human MECP2
Human
ELISA IHC
Unconjugated

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


Get Social With Us! Follow us on Facebook Follow us on Google+ Follow us on LinkedIn PSL Alliance Member
Copyright © 2017 LifeSpan BioSciences, Inc. All Rights Reserved Privacy Policy
Catalog Number