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MDK / Midkine

midkine (neurite growth-promoting factor 2)

Developmentally regulated, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development.

Gene Name: midkine (neurite growth-promoting factor 2)
Synonyms: MDK, ARAP, MK, MK1, NEGF2, Midkine, Retinoic acid inducible factor
Target Sequences: NM_002391 NP_002382.1 P21741

Publications (3)

1
High-level soluble expression, purification and characterization of active human midkine from Escherichia coli. Yan WK, Goette M, Hofmann G, Zaror I, Sim J. Protein expression and purification. 2010 70:270-6. (WB) [PubMed:19883768]
2
DNA damage repair alterations modulate M2 polarization of microglia to remodel the tumor microenvironment via the p53-mediated MDK expression in glioma. Meng X, Duan C, Pang H, Chen Q, Han B, Zha C, Dinislam M, Wu P, Li Z, Zhao S, Wang R, Lin L, Jiang C, Cai J. EBioMedicine. 2019 March;41:185-199. [Full Text Article] [PubMed:30773478] [PMC:PMC6442002]
3
Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer. Lim JS, Ibaseta A, Fischer MM, Cancilla B, O'Young G, Cristea S, Luca VC, Yang D, Jahchan NS, Hamard C, Antoine M, Wislez M, Kong C, Cain J, Liu YW, Kapoun AM, Garcia KC, Hoey T, Murriel CL, Sage J. Nature. 2017 May;545:360-364. [Full Text Article] [PubMed:28489825] [PMC:PMC5776014]

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ELISA Kits (30)
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MDK / Midkine (30)
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Guinea pig (1)
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DevKit DuoPlus (2)
1000 Wells (1)
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96-Well Microplate (3)
96-Well Strip Plate (20)
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Yes (1)
Cell Culture Supernatants (9)
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Citrate Plasma (2)
EDTA Plasma (2)
Heparin Plasma (2)
Plasma (18)
Serum (20)
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MDK / Midkine ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$782
MDK / Midkine ELISA Kit
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Sandwich
12 x 8-Well Microstrips
Human
32 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum
1 Plate/$479
MDK / Midkine ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
MDK / Midkine ELISA Kit
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Sandwich
96-Well Microplate
Human
0.123 - 30 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$700
MDK / Midkine ELISA Kit
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Development Kit
1000 Wells
Human
32 - 2000 pg/ml
Colorimetric - 405nm (ABTS)
1 Test/$540
MDK / Midkine ELISA Kit
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Competitive EIA
96-Well Strip Plate
Human
0.5 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
MDK / Midkine ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$818
MDK / Midkine ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
MDK / Midkine ELISA Kit
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Development Kit
Antibody Pair and Standard
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates
500 Wells/$1,182; 1000 Wells/$1,747
MDK / Midkine ELISA Kit
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Sandwich
96-Well Strip Plate
Chicken
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
MDK / Midkine ELISA Kit
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Sandwich
96-Well Strip Plate
Guinea pig
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
MDK / Midkine ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
MDK / Midkine ELISA Kit
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Sandwich
96-Well Strip Plate
Porcine
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
MDK / Midkine ELISA Kit
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Sandwich
96-Well Strip Plate
Rabbit
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
MDK / Midkine ELISA Kit
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Sandwich
96-Well Strip Plate
Sheep
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$760
MDK / Midkine ELISA Kit
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Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$783
MDK / Midkine ELISA Kit
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Sandwich CLIA
96-Well Strip Plate
Human
8 - 500 pg/ml
Chemiluminescent
Cell Lysates, Plasma, Serum
1 Plate/$649
MDK / Midkine ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Human
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
MDK / Midkine ELISA Kit
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Sandwich
96-Well Microplate
Human
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$795
MDK / Midkine ELISA Kit
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Sandwich
96-Well Strip Plate
Human
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$717
MDK / Midkine ELISA Kit
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Sandwich
96-Well Microplate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
MDK / Midkine ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
50 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
MDK / Midkine ELISA Kit
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Competitive EIA
96-Well Strip Plate
Mouse
250 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
MDK / Midkine ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
MDK / Midkine ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$958
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).