MDC1

mediator of DNA-damage checkpoint 1

Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AFX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1.

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Proteins (2)

Type

Recombinant (2)

Target

MDC1 (2)

Publications

No (2)

Tag

6His, N-terminus (1)

6His-SUMO, N-terminus (1)

Species

Human (2)

Source

E. coli (1)

Yeast (1)

Purification

Purified (2)

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Human MDC1 Protein (Recombinant 6His-SUMO, N-terminus) (aa1892-2082) - LS-G56735

Source:

E. coli

Tag:

6His-SUMO, N-terminus

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Human MDC1 Protein (Recombinant 6His, N-terminus) (aa1892-2082) - LS-G57309

Source:

Yeast

Tag:

6His, N-terminus

Price:

100 µg/$570; 20 µg/$395; 1 mg/$1,973

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