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MCNAA / BPHL

biphenyl hydrolase-like (serine hydrolase)

Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes. It is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol.

Gene Name: biphenyl hydrolase-like (serine hydrolase)
Synonyms: BPHL, MCNAA, Valacyclovir hydrolase, Valacyclovirase, VACVASE, BPH-RP
Target Sequences: NM_004332 NP_004323.2 Q86WA6

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).