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Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion.
Gene Name: | minichromosome maintenance complex binding protein |
Synonyms: | MCMBP, MCM-binding protein, C10orf119, MCM-BP |
Target Sequences: | NM_024834 NP_079110.1 Q9BTE3 |
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