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MCM4

minichromosome maintenance complex component 4

MCM4 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported.

Gene Name: minichromosome maintenance complex component 4
Synonyms: MCM4, CDC21 homolog, CDC54, HCdc21, NKGCD, p1-CDC21, NKCD, CDC21
Target Sequences: X74794 CAA52801.1 P33991

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Products
Proteins (8)
Over-Expression Lysate (4)
Recombinant (4)
MCM4 (8)
No (8)
GST (1)
GST, N-terminus (1)
Myc-DDK (Flag) (6)
Human (6)
293T Cells (2)
HEK 293 Cells (4)
Wheat Germ Extract (2)
Purified (1)
MCM4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
96.4 kDa
100 µg/$494
MCM4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
96.4 kDa
100 µg/$494
MCM4 Protein - 12.5% SDS-PAGE of human MCM4 stained with Coomassie Blue
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Wheat Germ Extract
GST
123 kDa
10 µg/$479; 25 µg/$670
MCM4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
96.4 kDa
20 µg/$150
MCM4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
96.4 kDa
20 µg/$150
MCM4 Protein - Purified recombinant protein MCM4 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
96.4 kDa
20 µg/$1,107
MCM4 Protein - Purified recombinant protein MCM4 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
96.4 kDa
20 µg/$1,107
MCM4 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
Viewing 1-8 of 8 product results


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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).