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Guanine nucleotide exchange factor (GEF) that modulates the Rho family of GTPases. Promotes the conversion of some member of the Rho family GTPase from the GDP-bound to the GTP-bound form. Isoform 1 exhibits no activity toward RHOA, RAC1 or CDC42. Isoform 2 exhibits decreased GEF activity toward CDC42. Isoform 3 exhibits a weak but significant activity toward RAC1 and CDC42. Isoform 4 exhibits significant activity toward RHOA and CDC42. The truncated DBL oncogene is active toward RHOA, RAC1 and CDC42.
Gene Name: | MCF.2 cell line derived transforming sequence |
Synonyms: | MCF2, DBL, Oncogene MCF2 (oncogene DBL), Proto-oncogene MCF-2, ARHGEF21, Proto-oncogene DBL |
Target Sequences: | NM_005369 NP_005360.3 P10911 |
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