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MCC

mutated in colorectal cancers

Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation.

Gene Name:	mutated in colorectal cancers
Synonyms:	MCC, MCC1, Protein MCC, Mutated in colorectal cancers
Target Sequences:	nm_002387 NP_002378.1 P23508

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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