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MC1R

melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)

This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation.

Gene Name: melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
Family/Subfamily: GPCR , Melanocortin
Synonyms: MC1R, CMM5, MC1 receptor, MC1-R, MSHR, Melanocortin receptor 1, Melanotropin receptor, Melanocortin 1 receptor, MSH-R, SHEP2
Target Sequences: NM_002386 NP_002377.4 Q01726

Filtered By: None
Target
mc1r (29)
Reactivity
Human (26)
Mouse (6)
Rat (1)
Chimpanzee (3)
Monkey (8)
Orangutan (3)
Application
IHC (12)
IHC-P (9)
WB (16)
ELISA (7)
IF (3)
Peptide-ELISA (1)
Host
rabbit (28)
mouse (1)
Isotype
IgG (12)
IgM (1)
Clonality
monoclonal mc (1)
polyclonal pc (28)
Format
AP Conjugated (1)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (3)
FITC Conjugated (3)
HRP Conjugated (3)
PE Conjugated (1)
Unconjugated (17)
Epitope
Cytoplasmic Domain (7)
C-Terminus (5)
3rd Cytoplasmic Domain (1)
Internal (1)
Val312 (1)
aa205-232 (1)
aa240-320 (1)
aa253-317 (1)
aa263-312 (1)
Publications
No (29)
Showing 1-25 out of 29 results
MC1R Antibody (Cytoplasmic Domain) IHC-plus™ LS-A1040
Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)

Rabbit Polyclonal to Human MC1R
Human, Monkey
IHC IHC-P
Unconjugated
MC1R Antibody (Cytoplasmic Domain, Biotin) IHC-plus™ LS-A100129
Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)

Rabbit Polyclonal to Human MC1R
Human, Monkey
IHC IHC-P
Biotin Conjugated
MC1R Antibody (Cytoplasmic Domain, FITC) IHC-plus™ LS-A100130
Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)

Rabbit Polyclonal to Human MC1R
Human, Monkey
IHC IHC-P
FITC Conjugated
MC1R Antibody (Cytoplasmic Domain, Azide-free, HRP) IHC-plus™ LS-A100131
Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)

Rabbit Polyclonal to Human MC1R
Human, Monkey
IHC IHC-P
HRP Conjugated, Azide-free
MC1R Antibody (Cytoplasmic Domain, AP) IHC-plus™ LS-A100127
Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)

Rabbit Polyclonal to Human MC1R
Human, Monkey
IHC IHC-P
AP Conjugated
MC1R Antibody (Cytoplasmic Domain, PE) IHC-plus™ LS-A100132
Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)

Rabbit Polyclonal to Human MC1R
Human, Monkey
IHC IHC-P
PE Conjugated
MC1R Antibody (Cytoplasmic Domain, APC) IHC-plus™ LS-A100128
Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)

Rabbit Polyclonal to Human MC1R
Human, Monkey
IHC IHC-P
APC Conjugated
MC1R Antibody (aa205-232) IHC-plus™ LS-B10498
Anti-MC1R antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B10498 dilution 1:100.
MC1R Antibody western blot of A375 cell line lysates (35 ug/lane). The MC1R antibody detected the MC1R protein (arrow).

Mouse Monoclonal (IgM) to Human MC1R
Human
IHC IHC-P WB
Unconjugated
MC1R Antibody LS-C8968

Rabbit Polyclonal (IgG) to Mouse MC1R
Mouse
ELISA WB
Unconjugated
MC1R Antibody (Internal) LS-C153483

Rabbit Polyclonal to Human MC1R
Human, Monkey
ELISA IHC WB
Unconjugated
MC1R Antibody LS-C332324
Immunohistochemistry of paraffin-embedded human kidney cancer tissue using MC1R antibody at dilution of 1:200 (x400 lens)
Immunohistochemistry of paraffin-embedded human kidney cancer tissue.

Rabbit Polyclonal (IgG) to Human MC1R
Mouse, Rat, Human
IHC WB
Unconjugated
MC1R Antibody (aa240-320) LS-C384454
Western blot of MC1-R antibody

Rabbit Polyclonal (IgG) to Human MC1R
Human
ELISA IF WB
Unconjugated
MC1R Antibody (aa253-317) LS-C185954
MC1 Receptor antibody [C2C3], C-term detects MC1R protein at cytosol and membrane on colon carcinoma by immunohistochemical analysis. Sample: Paraffin-embedded colon carcinoma. MC1 Receptor antibody [C2C3], C-term dilution:1:500.
Sample (30 ug of whole cell lysate). A: Molt-4 . 10% SDS PAGE. MC1R antibody diluted at 1:1000.

Rabbit Polyclonal to Human MC1R
Human
IHC IHC-P WB
Unconjugated
MC1R Antibody LS-C417071

Rabbit Polyclonal to Human MC1R
Human
IF WB
Unconjugated
MC1R Antibody (Val312) LS-C177159
Western blot of MC1-R (V312) pAb in extracts from COLO205 cells.

Rabbit Polyclonal to Human MC1R
Human
IF WB
Unconjugated
MC1R Antibody (3rd Cytoplasmic Domain) LS-C16499

Rabbit Polyclonal (IgG) to Mouse MC1R
Mouse
ELISA WB
Unconjugated
MC1R Antibody LS-C405709
Immunohistochemistry of Human gastric cancer using MC1R Polyclonal Antibody at dilution of 1:100.
Immunohistochemistry of Human gastric cancer using MC1R Polyclonal Antibody at dilution of 1:100.

Rabbit Polyclonal (IgG) to Human MC1R
Mouse, Human
ELISA IHC
Unconjugated
MC1R Antibody LS-C402431
Western blot analysis of Mouse intestinum tenue tissue , using MC1R Polyclonal Antibody at dilution of 1:1450.

Rabbit Polyclonal (IgG) to Human MC1R
Mouse, Human
ELISA WB
Unconjugated
MC1R Antibody (aa263-312) LS-C200234
Western blot of the lysates from HepG2 cells using MSHR antibody.

Rabbit Polyclonal (IgG) to Human MC1R
Human
Peptide-ELISA WB
Unconjugated
MC1R Antibody (C-Terminus) LS-C8969

Rabbit Polyclonal (IgG) to Mouse MC1R
Mouse
ELISA
Unconjugated
MC1R Antibody LS-C670652
Immunohistochemistry image at a dilution of 1:400 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0) . Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4 °C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Immunohistochemistry image at a dilution of 1:400 and staining in paraffin-embedded human melanoma cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0) . Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4 °C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Rabbit Polyclonal (IgG) to Human MC1R
Human
Unconjugated
MC1R Antibody (C-Terminus) LS-C169728
 This image was taken for the unconjugated form of this product. Other forms have not been tested.

Rabbit Polyclonal to Human MC1R
Human
WB
Unconjugated
MC1R Antibody (C-Terminus, Biotin) LS-C470732
 This image was taken for the unconjugated form of this product. Other forms have not been tested.

Rabbit Polyclonal to Human MC1R
Human, Chimpanzee, Orangutan
WB
Biotin Conjugated
MC1R Antibody (C-Terminus, FITC) LS-C470733
 This image was taken for the unconjugated form of this product. Other forms have not been tested.

Rabbit Polyclonal to Human MC1R
Human, Chimpanzee, Orangutan
WB
FITC Conjugated
MC1R Antibody LS-C662033
Western blot - Anti-MC1 Receptor Picoband Antibody

Rabbit Polyclonal to Human MC1R
Human
WB
Unconjugated

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If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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