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MC1R

melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)

This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation.

Gene Name: melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
Family/Subfamily: GPCR , Melanocortin
Synonyms: MC1R, CMM5, MC1 receptor, MC1-R, MSHR, Melanocortin receptor 1, Melanotropin receptor, Melanocortin 1 receptor, MSH-R, SHEP2
Target Sequences: NM_002386 NP_002377.4 Q01726
Featured Image

Featured MC1R Antibody

LS-A1040 is a rabbit polyclonal antibody that LifeSpan has tested extensively in immunohistochemistry (IHC) and is an excellent antibody for use in formalin-fixed paraffin embedded tissues. Multiple tissues were immunolabeled and the results were interpreted by a LifeSpan pathologist. This image shows an example of staining in formalin-fixed paraffin embedded tissue. Learn more about our IHC Validation procedure. All LSBio antibodies are 100% guaranteed.


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Target Reactivity Applications Host Isotype Clonality Clone Format Epitope Publications Type
MC1R Rabbit Polyclonal Unconjugated Human, Monkey IHC-P Cytoplasmic Domain No Primary Available
Anti-MC1R Antibody (Cytoplasmic Domain) IHC-plus™ LS-A1040
Immunohistochemistry - Paraffin Image
Immunohistochemistry - Paraffin Image
Rabbit Polyclonal to Human MC1R
Human, Monkey
IHC - Paraffin
Unconjugated
MC1R Mouse IgM Monoclonal Unconjugated Human IHC-P, WB aa205-232 No Primary
Anti-MC1R Antibody (aa205-232) IHC-plus™ LS-B10498
Immunohistochemistry Image
Western blot Image
Mouse Monoclonal (IgM) to Human MC1R
Human
IHC - Paraffin, Western blot
Unconjugated
MC1R Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat IHC, WB No Primary
Anti-MC1R Antibody LS-C332324
Immunohistochemistry Image
Western blot Image
Rabbit Polyclonal (IgG) to Human MC1R
Human, Mouse, Rat
IHC, Western blot
Unconjugated
MC1R Rabbit Polyclonal Unconjugated Human IHC-P, WB aa253-317 No Primary
Anti-MC1R Antibody (aa253-317) LS-C185954
Immunohistochemistry Image
Western blot Image
Rabbit Polyclonal to Human MC1R
Human
IHC - Paraffin, Western blot
Unconjugated
MC1R Rabbit Polyclonal Unconjugated Human, Monkey IHC, WB, ELISA Internal No Primary
Anti-MC1R Antibody (Internal) LS-C153483
Rabbit Polyclonal to Human MC1R
Human, Monkey
IHC, Western blot, ELISA
Unconjugated
MC1R Rabbit IgG Polyclonal Unconjugated Human, Mouse IHC, ELISA No Primary
Anti-MC1R Antibody LS-C405709
Immunohistochemistry Image
Immunohistochemistry Image
Rabbit Polyclonal (IgG) to Human MC1R
Human, Mouse
IHC, ELISA
Unconjugated
MC1R Rabbit IgG Polyclonal Unconjugated Human IF, WB, ELISA aa268-317 No Primary
Anti-MC1R Antibody (aa268-317) LS-C120748
Immunofluorescence Image
Western blot Image
Rabbit Polyclonal (IgG) to Human MC1R
Human
Immunofluorescence, Western blot, ELISA
Unconjugated
MC1R Rabbit IgG Polyclonal Unconjugated Human WB, ELISA aa263-312 No Primary
Anti-MC1R Antibody (aa263-312) LS-C200234
Western blot Image
Rabbit Polyclonal (IgG) to Human MC1R
Human
Western blot, ELISA
Unconjugated
MC1R Rabbit Polyclonal Unconjugated Human IF, WB Val312 No Primary
Anti-MC1R Antibody (Val312) LS-C177159
Western blot Image
Rabbit Polyclonal to Human MC1R
Human
Immunofluorescence, Western blot
Unconjugated
MC1R Rabbit Polyclonal Unconjugated Human WB C-Terminus No Primary
Anti-MC1R Antibody (C-Terminus) LS-C169728
Western blot Image
Rabbit Polyclonal to Human MC1R
Human
Western blot
Unconjugated
MC1R Rabbit IgG Polyclonal Unconjugated Human IF, WB, ELISA aa240-320 No Primary
Anti-MC1R Antibody (aa240-320) LS-C384454
Western blot Image
Rabbit Polyclonal (IgG) to Human MC1R
Human
Immunofluorescence, Western blot, ELISA
Unconjugated
MC1R Rabbit Polyclonal Unconjugated Human IF, WB No Primary
Anti-MC1R Antibody LS-C417071
Rabbit Polyclonal to Human MC1R
Human
Immunofluorescence, Western blot
Unconjugated
MC1R Rabbit IgG Polyclonal Unconjugated Human, Mouse WB, ELISA No Primary
Anti-MC1R Antibody LS-C402431
Western blot Image
Rabbit Polyclonal (IgG) to Human MC1R
Human, Mouse
Western blot, ELISA
Unconjugated
MC1R Rabbit Polyclonal HRP Conjugated Human, Chimpanzee, Orangutan WB C-Terminus No Primary
Anti-MC1R Antibody (C-Terminus, HRP) LS-C470734
Western blot Image
Rabbit Polyclonal to Human MC1R
Human, Chimpanzee, Orangutan
Western blot
HRP Conjugated
MC1R Rabbit Polyclonal FITC Conjugated Human, Chimpanzee, Orangutan WB C-Terminus No Primary
Anti-MC1R Antibody (C-Terminus, FITC) LS-C470733
Western blot Image
Rabbit Polyclonal to Human MC1R
Human, Chimpanzee, Orangutan
Western blot
FITC Conjugated
MC1R Rabbit Polyclonal Biotin Conjugated Human, Chimpanzee, Orangutan WB C-Terminus No Primary
Anti-MC1R Antibody (C-Terminus, Biotin) LS-C470732
Western blot Image
Rabbit Polyclonal to Human MC1R
Human, Chimpanzee, Orangutan
Western blot
Biotin Conjugated
MC1R Rabbit IgG Polyclonal Unconjugated Mouse WB, ELISA No Primary
Anti-MC1R Antibody LS-C8968
Rabbit Polyclonal (IgG) to Mouse MC1R
Mouse
Western blot, ELISA
Unconjugated
MC1R Rabbit IgG Polyclonal Unconjugated Mouse WB, ELISA 3rd Cytoplasmic Domain No Primary
Anti-MC1R Antibody (3rd Cytoplasmic Domain) LS-C16499
Rabbit Polyclonal (IgG) to Mouse MC1R
Mouse
Western blot, ELISA
Unconjugated
MC1R Rabbit IgG Polyclonal Unconjugated Mouse ELISA C-Terminus No Primary
Anti-MC1R Antibody (C-Terminus) LS-C8969
Rabbit Polyclonal (IgG) to Mouse MC1R
Mouse
ELISA
Unconjugated
Target Corresponding Antibodies
MC1R
MC1R Blocking Peptide - LS-E28106
LS-E28106
MC1R
MC1R
MC1R Blocking Peptide - LS-E28108
LS-E28108
MC1R
MC1R
MC1R Blocking Peptide - LS-E39722
LS-E39722
MC1R
MC1R
MC1R Blocking Peptide - LS-E39723
LS-E39723
MC1R
MC1R
MC1R Antibody Blocking Peptide - LS-E39737
LS-E39737
MC1R
LS-A1040
Type Target Tag Species Source Purified Biological Activity Known Endotoxin Level Animal-Free
Recombinant MC1R GST Human Wheat
Human MC1R Recombinant (GST) Protein - LS-G29283
Wheat Wheat Germ Extract
GST
Unpurified / Lyophilized
61.1 kDa

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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