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MC1R

melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)

This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation.

Gene Name: melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
Family/Subfamily: GPCR , Melanocortin
Synonyms: MC1R, CMM5, MC1 receptor, MC1-R, MSHR, Melanocortin receptor 1, Melanotropin receptor, Melanocortin 1 receptor, MSH-R, SHEP2
Target Sequences: NM_002386 NP_002377.4 Q01726

Filtered By: None
Target
mc1r (19)
Reactivity
Human (16)
Mouse (6)
Rat (1)
Chimpanzee (3)
Monkey (2)
Orangutan (3)
Application
IHC (3)
IHC-P (3)
WB (15)
ELISA (8)
IF (3)
Host
rabbit (18)
mouse (1)
Isotype
IgG (8)
IgM (1)
Clonality
monoclonal mc (1)
polyclonal pc (18)
Format
Biotin Conjugated (1)
FITC Conjugated (1)
HRP Conjugated (1)
Unconjugated (16)
Epitope
C-Terminus (5)
3rd Cytoplasmic Domain (1)
Cytoplasmic Domain (1)
Internal (1)
Val312 (1)
aa205-232 (1)
aa240-320 (1)
aa253-317 (1)
aa263-312 (1)
Publications
No (19)
Showing 1-19 out of 19 results
Anti-MC1R Antibody (Cytoplasmic Domain) IHC-plus™ LS-A1040

Rabbit Polyclonal to Human MC1R
Human, Monkey
IHC-P
Unconjugated
Anti-MC1R Antibody (aa205-232) IHC-plus™ LS-B10498

Mouse Monoclonal (IgM) to Human MC1R
Human
IHC-P WB
Unconjugated
Anti-MC1R Antibody LS-C8968

Rabbit Polyclonal (IgG) to Mouse MC1R
Mouse
ELISA WB
Unconjugated
Anti-MC1R Antibody (Internal) LS-C153483

Rabbit Polyclonal to Human MC1R
Human, Monkey
ELISA IHC WB
Unconjugated
Anti-MC1R Antibody LS-C332324

Rabbit Polyclonal (IgG) to Human MC1R
Mouse, Rat, Human
IHC WB
Unconjugated
Anti-MC1R Antibody (aa240-320) LS-C384454

Rabbit Polyclonal (IgG) to Human MC1R
Human
ELISA IF WB
Unconjugated
Anti-MC1R Antibody LS-C417071

Rabbit Polyclonal to Human MC1R
Human
IF WB
Unconjugated
Anti-MC1R Antibody (3rd Cytoplasmic Domain) LS-C16499

Rabbit Polyclonal (IgG) to Mouse MC1R
Mouse
ELISA WB
Unconjugated
Anti-MC1R Antibody (Val312) LS-C177159

Rabbit Polyclonal to Human MC1R
Human
IF WB
Unconjugated
Anti-MC1R Antibody LS-C405709

Rabbit Polyclonal (IgG) to Human MC1R
Mouse, Human
ELISA IHC
Unconjugated
Anti-MC1R Antibody (aa263-312) LS-C200234

Rabbit Polyclonal (IgG) to Human MC1R
Human
ELISA WB
Unconjugated
Anti-MC1R Antibody LS-C402431

Rabbit Polyclonal (IgG) to Human MC1R
Mouse, Human
ELISA WB
Unconjugated
Anti-MC1R Antibody (C-Terminus) LS-C8969

Rabbit Polyclonal (IgG) to Mouse MC1R
Mouse
ELISA
Unconjugated
Anti-MC1R Antibody (aa253-317) LS-C185954

Rabbit Polyclonal to Human MC1R
Human
IHC-P WB
Unconjugated
Anti-MC1R Antibody (C-Terminus) LS-C169728

Rabbit Polyclonal to Human MC1R
Human
WB
Unconjugated
Anti-MC1R Antibody (C-Terminus, HRP) LS-C470734

Rabbit Polyclonal to Human MC1R
Human, Chimpanzee, Orangutan
WB
HRP Conjugated
Anti-MC1R Antibody (C-Terminus, Biotin) LS-C470732

Rabbit Polyclonal to Human MC1R
Human, Chimpanzee, Orangutan
WB
Biotin Conjugated
Anti-MC1R Antibody (C-Terminus, FITC) LS-C470733

Rabbit Polyclonal to Human MC1R
Human, Chimpanzee, Orangutan
WB
FITC Conjugated
Anti-MC1R Antibody LS-C662033

Rabbit Polyclonal to Human MC1R
Human
Unconjugated

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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