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MASP1 / MASP

mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)

MASP1 / MASP is a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. Alternate splicing results in multiple transcript variants.

Gene Name: mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
Family/Subfamily: Protease , Serine S1
Synonyms: MASP1, 3MC1, Complement factor MASP-3, CRARF, MAP1, MAp44, MASP3, MASP, MASP-3, PRSS5, Serine protease 5, MASP-1, RaRF, CRARF1
Target Sequences: NM_001879 NP_001870.3 P48740

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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).