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E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I, CD4 and ICAM1, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
Gene Name: | membrane-associated ring finger (C3HC4) 9 |
Synonyms: | MARCH9, RING finger protein 179, RNF179, MARCH-IX |
Target Sequences: | NM_138396 NP_612405.2 Q86YJ5 |
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