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MARCH8

membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase

E3 ubiquitin-protein ligase that mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. May also promote ubiquitination and endocytosis of TFRC and FAS.

Gene Name:	membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
Synonyms:	MARCH8, C-MIR, RING finger protein 178, RNF178, MARCH-VIII, MIR
Target Sequences:	NP_659458.2 Q5T0T0

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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