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MARCH2

membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase

E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in endosomal trafficking through interaction with STX6.

Gene Name: membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase
Synonyms: MARCH2, HSPC240, RING finger protein 172, RNF172, MARCH-II
Target Sequences: NM_016496 NP_057580.3 Q9P0N8

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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).