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MARCH2
membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase
E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in endosomal trafficking through interaction with STX6.
| Gene Name: | membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase |
| Synonyms: | MARCH2, HSPC240, RING finger protein 172, RNF172, MARCH-II |
| Target Sequences: | NM_016496 NP_057580.3 Q9P0N8 |
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