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MAPT / Tau
microtubule-associated protein tau
Tau promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. In Alzheimer disease, the neuronal cytoskeleton in the brain is progressively disrupted and replaced by tangles of paired helical filaments (PHF) and straight filaments, mainly composed of hyperphosphorylated forms of TAU.
| Gene Name: | microtubule-associated protein tau |
| Synonyms: | MAPT, FTDP-17, MSTD, Neurofibrillary tangle protein, PHF-tau, MTBT2, PPND, DDPAC, MAPTL, MTBT1, Paired helical filament-tau, TAU |
| Target Sequences: | NM_016835 P10636 |
Publications (3)
1
Hyperphosphorylation and aggregation of Tau in laforin-deficient mice, an animal model for Lafora disease. Puri R, Suzuki T, Yamakawa K, Ganesh S. The Journal of biological chemistry. 2009 284:22657-63. (IHC, WB)
[PubMed:19542233]
[PMC:PMC2755673]
2
Effect of carbamylated erythropoietin on major histocompatibility complex expression and neural differentiation of human neural stem cells. Fu ZQ, Shao QL, Shen JL, Zhang YJ, Zhao XX, Yao L. Journal of neuroimmunology. 2010 221:15-24. (ICC, WB)
[PubMed:20163877]
3
Serum levels of tau protein increase according to the severity of the injury in DAI rat model. Keisuke Tomita, Taka-Aki Nakada, Taku Oshima, Rui Kawaguchi, Shigeto Oda. F1000Research. 2020 December;9:29. [Full Text Article]
[PubMed:33299544]
[PMC:PMC7707115]
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Publications
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(336)
Cancer Pathology
Cancer
MAPT / Tau Mouse anti-Human Monoclonal (MCA-2E9) Antibody
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
MAPT / Tau Rabbit anti-Human Polyclonal (680-760 aa) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
MAPT / Tau Rabbit anti-Human Polyclonal (aa677-707) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
MAPT / Tau Rabbit anti-Human Polyclonal (aa677-707) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
MAPT / Tau Rabbit anti-Human Polyclonal (aa677-707) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
MAPT / Tau Mouse anti-Human Monoclonal (Preservative Free) Antibody
Human
ELISA, WB
Unconjugated, Preservative Free
20 µg/$242; 100 µg/$304; 200 µg/$334; 500 µg/$452
MAPT / Tau Mouse anti-Human Monoclonal (Preservative Free) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated, Preservative Free
50 µg/$343
MAPT / Tau Mouse anti-Human Monoclonal Antibody
Rat, Human
WB
Unconjugated
100 µg/$880
MAPT / Tau Mouse anti-Bovine Monoclonal (Magnetic beads) (TAU-93) Antibody
Mouse, Bovine, Rat, Human
IP
Magnetic beads Conjugated
100 µg/$399
MAPT / Tau Rabbit anti-Human Monoclonal (pSer202/pThr205) (AH36) Antibody
Human
DB, ELISA, IF, WB
Unconjugated
100 µg/$544
MAPT / Tau Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
0.05 mg/$440
MAPT / Tau Mouse anti-Human Monoclonal (pThr231) (13B10) Antibody
Human
ELISA, IP, WB
Unconjugated
20 µg/$242; 100 µg/$304; 200 µg/$334; 500 µg/$452
MAPT / Tau Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Dog, Bovine, Rat, Pig, Human
ICC, IF, IHC, IHC-P, IP, WB
Unconjugated
50 µl/$460
MAPT / Tau Rabbit anti-Human Polyclonal (pThr534/217) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
MAPT / Tau Rabbit anti-Human Polyclonal (pSer262) Antibody
IF, IHC, WB
Unconjugated
20 µl/$299; 100 µl/$431
MAPT / Tau Rabbit anti-Human Polyclonal (pThr212) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µl/$334; 100 µl/$397
MAPT / Tau Rabbit anti-Human Polyclonal (pThr205) Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µl/$328; 100 µl/$419
MAPT / Tau Rabbit anti-Human Polyclonal (pThr212) Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
100 µg/$357
MAPT / Tau Rabbit anti-Human Polyclonal (pThr205) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
MAPT / Tau Mouse anti-Human Monoclonal (pSer396) Antibody
Mouse, Rat, Human
IP, WB
Unconjugated
100 µl/$689
MAPT / Tau Rabbit anti-Human Polyclonal (pThr212) Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
MAPT / Tau Rabbit anti-Human Polyclonal (aa240-450) Antibody
Mouse, Rat, Human
IHC, IHC-Fr, IHC-P, WB
Unconjugated
250 µg/$614
MAPT / Tau Rabbit anti-Human Polyclonal Antibody
Rabbit, Mouse, Goat, Dog, Bovine, Rat, Bat, Human, Monkey
IHC, IHC-P, WB
Unconjugated
50 µl/$460
MAPT / Tau Rabbit anti-Human Polyclonal (Val256) Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
50 µl/$321; 100 µl/$403
MAPT / Tau Rabbit anti-Human Polyclonal (Ser404) Antibody
Rabbit, Mouse, Goat, Dog, Bovine, Rat, Horse, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100 µg/$460
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