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Shirley, MA 01464
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20700 44th Avenue W
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MAPRE1 / EB1
microtubule-associated protein, RP/EB family, member 1
MAPRE1 / EB1 was first identified by its binding to the APC protein which is often mutated in familial and sporadic forms of colorectal cancer. This protein localizes to microtubules, especially the growing ends, in interphase cells. During mitosis, the protein is associated with the centrosomes and spindle microtubules. The protein also associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein. Because of these associations, it is thought that this protein is involved in the regulation of microtubule structures and chromosome stability. This gene is a member of the RP/EB family.
| Gene Name: | microtubule-associated protein, RP/EB family, member 1 |
| Synonyms: | MAPRE1, APC-binding protein EB1, EB1, End-binding protein 1 |
| Target Sequences: | NM_012325 NP_036457.1 Q15691 |
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