MAPKAPK5 / PRAK

mitogen-activated protein kinase-activated protein kinase 5

Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, inducing F-actin rearrangement.

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Products

Proteins (4)

Type

Recombinant (4)

Target

MAPKAPK5 / PRAK (4)

Publications

No (4)

Tag

GST (1)

GST, N-terminus (1)

His, N-Terminal (1)

His-GST (1)

Species

Human (4)

Source

Baculovirus (1)

E. coli (1)

Wheat Germ Extract (2)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (1)

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Human MAPKAPK5 / PRAK Protein (Recombinant GST) (Full Length) - LS-G31204

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

77.55 kDa

Price:

10 µg/$479; 25 µg/$670

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Human MAPKAPK5 / PRAK Protein (Recombinant GST, N-terminus) (aa371-471) - LS-G60777

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human MAPKAPK5 / PRAK Protein (Recombinant His-GST) (Met1-Gln471) - LS-G97682

Source:

Baculovirus

Tag:

His-GST

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

82 kDa

Price:

50 µg/$707

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Human MAPKAPK5 / PRAK Protein (Recombinant His, N-Terminal) - LS-G144141

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

53.9 kDa

Price:

50 µg/$419

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