Products
Research Areas
COVID-19
Resources
Login
Quick Order
Cart Cart lightblue
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Contact Us

Locations


Orders Processing,
Shipping & Receiving,
Warehouse

2 Shaker Rd Suites
B001/B101
Shirley, MA 01464


Production Lab

Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036

Telephone Numbers



Tel: +1 (206) 374-1102
Fax: +1 (206) 577-4565

Contact Us



Additional Contact Details

Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order

MAPKAPK5 / PRAK

mitogen-activated protein kinase-activated protein kinase 5

Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, inducing F-actin rearrangement.

Gene Name: mitogen-activated protein kinase-activated protein kinase 5
Family/Subfamily: Protein Kinase , MAPKAPK
Synonyms: MAPKAPK5, MAPKAP kinase 5, MAPKAP-K5, MK5, p38-regulated/activated kinase, MAPKAPK-5, PRAK, MK-5, p38-regulated protein kinase
Target Sequences: NM_003668 NP_003659.2 Q8IW41

☰ Filters
Products
Proteins (4)
Recombinant (4)
MAPKAPK5 / PRAK (4)
No (4)
GST (1)
GST, N-terminus (1)
His, N-Terminal (1)
His-GST (1)
Human (4)
Baculovirus (1)
E. coli (1)
Wheat Germ Extract (2)
Purified (2)
Low endotoxin level (1)
MAPKAPK5 / PRAK Protein - 12.5% SDS-PAGE of human MAPKAPK5 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
77.55 kDa
10 µg/$479; 25 µg/$670
MAPKAPK5 / PRAK Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
Select
Baculovirus
His-GST
Less than 1.0 EU/µg protein (determined by LAL method).
82 kDa
50 µg/$707
MAPKAPK5 / PRAK Protein
Select
E. coli
His, N-Terminal
53.9 kDa
50 µg/$419
Viewing 1-4 of 4 product results


Filtered By:
Products: Proteins


If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).