MAPKAPK2 / MAPKAP Kinase 2

mitogen-activated protein kinase-activated protein kinase 2

Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, ELAVL1, HNRNPA0, HSF1, HSP27/HSPB1, KRT18, KRT20, LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins ELAVL1, HNRNPA0, PABPC1 and TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing transcript. Also involved in late G2/M checkpoint following DNA damage through a process of post-transcriptional mRNA stabilization: following DNA damage, relocalizes from nucleus to cytoplasm and phosphorylates HNRNPA0 and PARN, leading to stabilize GADD45A mRNA. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3.

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Products

Proteins (10)

Type

Over-Expression Lysate (4)

Recombinant (6)

Target

MAPKAPK2 / MAPKAP Kinase 2 (10)

Publications

No (10)

Tag

GST (1)

GST, N-terminus (1)

His-T7 (2)

Myc-DDK (Flag) (6)

Species

Human (7)

Mouse (1)

Source

293T Cells (2)

E. coli (2)

HEK 293 Cells (4)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human MAPKAPK2 / MAPKAP Kinase 2 Protein (Recombinant His-T7) (aa139-367) - LS-G13851

Source:

E. coli

Tag:

His-T7

Molecular Weight:

30.3 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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MAPKAPK2 / MAPKAP Kinase 2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G108541

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.4 kDa

Price:

100 µg/$494

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MAPKAPK2 / MAPKAP Kinase 2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G116433

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42 kDa

Price:

100 µg/$494

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Mouse MAPKAPK2 / MAPKAP Kinase 2 Protein (Recombinant His-T7) (aa117-337) - LS-G24332

Source:

E. coli

Tag:

His-T7

Molecular Weight:

29.1 kDa

Price:

10 µg/$282; 50 µg/$447; 100 µg/$715; 200 µg/$892; 1 mg/$2,005; 500 µg/$1,543; 5 mg/$3,123; 2 mg/$2,192

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Human MAPKAPK2 / MAPKAP Kinase 2 Protein (Recombinant GST, N-terminus) (aa302-400) - LS-G61054

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human MAPKAPK2 / MAPKAP Kinase 2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77234

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.4 kDa

Price:

20 µg/$150

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Human MAPKAPK2 / MAPKAP Kinase 2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77235

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42 kDa

Price:

20 µg/$150

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Human MAPKAPK2 / MAPKAP Kinase 2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66242

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.4 kDa

Price:

20 µg/$1,107

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Human MAPKAPK2 / MAPKAP Kinase 2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66241

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42 kDa

Price:

20 µg/$1,107

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Human MAPKAPK2 / MAPKAP Kinase 2 Protein (Recombinant GST) (Full Length) - LS-G31556

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

72 kDa

Price:

10 µg/$479; 25 µg/$670

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