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MAPKAPK2 / MAPKAP Kinase 2

mitogen-activated protein kinase-activated protein kinase 2

Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, ELAVL1, HNRNPA0, HSF1, HSP27/HSPB1, KRT18, KRT20, LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins ELAVL1, HNRNPA0, PABPC1 and TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing transcript. Also involved in late G2/M checkpoint following DNA damage through a process of post-transcriptional mRNA stabilization: following DNA damage, relocalizes from nucleus to cytoplasm and phosphorylates HNRNPA0 and PARN, leading to stabilize GADD45A mRNA. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3.

Gene Name: mitogen-activated protein kinase-activated protein kinase 2
Family/Subfamily: Protein Kinase , MAPKAPK
Synonyms: MAPKAPK2, MK-2, MAP KAP Kinase 2, MAPKAP kinase 2, MK2, MAPKAP-K2, MAPKAPK-2
Target Sequences: NM_004759 NP_004750.1 P49137

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Products
Proteins (10)
Over-Expression Lysate (4)
Recombinant (6)
MAPKAPK2 / MAPKAP Kinase 2 (10)
No (10)
GST (1)
GST, N-terminus (1)
His-T7 (2)
Myc-DDK (Flag) (6)
Human (7)
Mouse (1)
293T Cells (2)
E. coli (2)
HEK 293 Cells (4)
Wheat Germ Extract (2)
Purified (1)
MAPKAPK2 / MAPKAP Kinase 2 Protein - Recombinant Mitogen Activated Protein Kinase Activated Protein Kinase 2 By SDS-PAGE
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E. coli
His-T7
30.3 kDa
10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148
MAPKAPK2 / MAPKAP Kinase 2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
45.4 kDa
100 µg/$494
MAPKAPK2 / MAPKAP Kinase 2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
42 kDa
100 µg/$494
MAPKAPK2 / MAPKAP Kinase 2 Protein - Recombinant  Mitogen Activated Protein Kinase Activated Protein Kinase 2 By SDS-PAGE
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E. coli
His-T7
29.1 kDa
10 µg/$282; 50 µg/$447; 100 µg/$715; 200 µg/$892; 1 mg/$2,005; 500 µg/$1,543; 5 mg/$3,123; 2 mg/$2,192
MAPKAPK2 / MAPKAP Kinase 2 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
MAPKAPK2 / MAPKAP Kinase 2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
45.4 kDa
20 µg/$150
MAPKAPK2 / MAPKAP Kinase 2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
42 kDa
20 µg/$150
MAPKAPK2 / MAPKAP Kinase 2 Protein - Purified recombinant protein MAPKAPK2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
45.4 kDa
20 µg/$1,107
MAPKAPK2 / MAPKAP Kinase 2 Protein - Purified recombinant protein MAPKAPK2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
42 kDa
20 µg/$1,107
MAPKAPK2 / MAPKAP Kinase 2 Protein - 12.5% SDS-PAGE of human MAPKAPK2 stained with Coomassie Blue
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Wheat Germ Extract
GST
72 kDa
10 µg/$479; 25 µg/$670
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).