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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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MAPK9 / JNK2

mitogen-activated protein kinase 9

Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2. In turn, MAPK9/JNK2 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. In response to oxidative or ribotoxic stresses, inhibits rRNA synthesis by phosphorylating and inactivating the RNA polymerase 1-specific transcription initiation factor RRN3. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including TP53 and YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Upon T-cell receptor (TCR) stimulation, is activated by CARMA1, BCL10, MAP2K7 and MAP3K7/TAK1 to regulate JUN protein levels. Plays an important role in the osmotic stress-induced epithelial tight-junctions disruption. When activated, promotes beta-catenin/CTNNB1 degradation and inhibits the canonical Wnt signaling pathway. Participates also in neurite growth in spiral ganglion neurons.MAPK9 isoforms display different binding patterns: alpha-1 and alpha-2 preferentially bind to JUN, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it.

Gene Name: mitogen-activated protein kinase 9
Family/Subfamily: Protein Kinase , MAPK
Synonyms: MAPK9, C-Jun kinase 2, C-Jun N-terminal kinase 2, JNK2B, JNK2, JNK2ALPHA, MAP kinase 9, p54a, JNK2BETA, PRKM9, SAPK, MAPK 9, p54aSAPK, SAPK1a, JNK-55, JNK2A, Jun kinase
Target Sequences: NM_002752 NP_002743.3 P45984

Publications (1)

1
Cerebral ischemia provokes a profound exchange of activated JNK isoforms in brain mitochondria. Zhao Y, Herdegen T. Molecular and cellular neurosciences. 2009 41:186-95. (WB, IP) [PubMed:19289169]

Filtered by: None
Target
MAPK9 / JNK2 (72)
Reactivity
Human (68)
Mouse (42)
Rat (30)
Bat (7)
Bovine (5)
Chicken (5)
Chimpanzee (3)
Dog (14)
Gibbon (3)
Goat (4)
Guinea pig (6)
Hamster (2)
Horse (5)
Monkey (12)
Pig (7)
Rabbit (8)
Sheep (1)
Xenopus (4)
Zebrafish (4)
Application
IHC (35)
IHC-P (14)
WB (66)
Flo (1)
ELISA (29)
ICC (5)
IF (15)
IP (8)
Peptide-ELISA (3)
RNAi (1)
Host
rabbit (55)
mouse (13)
goat (2)
chicken (1)
sheep (1)
Isotype
Ig (1)
IgG (28)
IgG1 (10)
IgG1,k (1)
Clonality
monoclonal mc (13)
polyclonal pc (59)
Clone
1C1-3A8 (1)
OTI1A1 (2)
OTI2D11 (2)
OTI2G3 (2)
OTI2H3 (2)
OTI4D1 (2)
Format
AP Conjugated (1)
APC (1)
APC Conjugated (2)
Azide-free (1)
Biotin Conjugated (4)
Carrier-free (5)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (4)
HRP Conjugated (4)
PE Conjugated (2)
Unconjugated (53)
Epitope
aa130-387 (8)
aa206-233 (8)
aa1-424 (4)
aa40-89 (4)
aa217-230 (2)
220-300 aa, Internal (1)
C-Terminus (1)
Internal (1)
N-Terminus (1)
Phe280 (1)
Thr183/ (1)
aa1-16 (1)
aa246-295 (1)
aa257-288 (1)
aa373-389 (1)
pThr183/Tyr185 (1)
pThr183/pTyr185 (1)
Publications
No (72)
Showing 1-25 of 72 results

IHC-plus™ MAPK9 / JNK2 Antibody (clone 1C1-3A8) LS-B6137
Mouse Monoclonal [clone 1C1-3A8] (IgG1,k) to Human MAPK9 / JNK2
Human
ELISA, IHC, IHC-P, RNAi, WB
Unconjugated
50µg  $495.00
Anti-MAPK9 / JNK2 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Western blot of MAPK9 expression in transfected 293T cell line by MAPK9 monoclonal antibody.

IHC-plus™ MAPK9 / JNK2 Antibody (aa373-389) LS-B2052
Rabbit Polyclonal (IgG) to Human MAPK9 / JNK2
Rabbit, Bovine, Pig, Bat, Human
IHC, IHC-P, WB
Unconjugated
50µg 0.5mg/ml  $425.00
Anti-MAPK9 / JNK2 antibody IHC of human brain-cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Western blot analysis for JNK2 using antibody at 2 ug/ml on 20 ugs of A431 whole cell lysate.

IHC-plus™ MAPK9 / JNK2 Antibody (N-Terminus) LS-B1829
Rabbit Polyclonal to Human MAPK9 / JNK2
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µg 0.5mg/ml  $425.00
Anti-MAPK9 / JNK2 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.

IHC-plus™ MAPK9 / JNK2 Antibody (aa217-230) LS-B11182
Goat Polyclonal to Human MAPK9 / JNK2
Rabbit, Mouse, Rat, Bat, Human, Monkey
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µg 0.5mg/ml  $425.00
Anti-MAPK9 / JNK2 / SAPK antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
MAPK9 antibody (0.5 ug/ml) staining of Human Cerebellum lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

MAPK9 / JNK2 Antibody LS-C335141
Rabbit Polyclonal (IgG) to Human MAPK9 / JNK2
Mouse, Human
ICC, IF, IHC, IP, WB
Unconjugated
50µl  $275.00; 100µl  $355.00; 200µl  $455.00
Immunohistochemistry of paraffin-embedded human breast cancer using MAPK9 antibodyat dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded mouse brain using MAPK9 antibodyat dilution of 1:100 (40x lens).

MAPK9 / JNK2 Antibody (clone OTI4D1) LS-C174575
Mouse Monoclonal [clone OTI4D1] (IgG1) to Human MAPK9 / JNK2
Mouse, Dog, Human
IF, IHC, IHC-P, WB
Unconjugated
100µl 1mg/ml  $345.00
IHC of paraffin-embedded Human pancreas tissue using anti-MAPK9 mouse monoclonal antibody.
IHC of paraffin-embedded Human tonsil using anti-MAPK9 mouse monoclonal antibody.

MAPK9 / JNK2 Antibody (clone OTI4D1, Carrier-free) LS-C787923
Mouse Monoclonal [clone OTI4D1] (IgG1) to Human MAPK9 / JNK2
Mouse, Dog, Human
IF, IHC, WB
Unconjugated, Carrier-free
100µg  $395.00
IHC of paraffin-embedded Human pancreas tissue using anti-MAPK9 mouse monoclonal antibody.
IHC of paraffin-embedded Human tonsil using anti-MAPK9 mouse monoclonal antibody.

MAPK9 / JNK2 Antibody (clone OTI2G3) LS-C174574
Mouse Monoclonal [clone OTI2G3] (IgG1) to Human MAPK9 / JNK2
Mouse, Dog, Rat, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
100µl 1mg/ml  $345.00
IHC of paraffin-embedded Human pancreas tissue using anti-MAPK9 mouse monoclonal antibody.
IHC of paraffin-embedded Human tonsil using anti-MAPK9 mouse monoclonal antibody.

MAPK9 / JNK2 Antibody (clone OTI2G3, Carrier-free) LS-C797683
Mouse Monoclonal [clone OTI2G3] (IgG1) to Human MAPK9 / JNK2
Mouse, Dog, Rat, Human, Monkey
IF, IHC, WB
Unconjugated, Carrier-free
100µg  $395.00
IHC of paraffin-embedded Human pancreas tissue using anti-MAPK9 mouse monoclonal antibody.
IHC of paraffin-embedded Human tonsil using anti-MAPK9 mouse monoclonal antibody.

MAPK9 / JNK2 Antibody (clone OTI1A1) LS-C174576
Mouse Monoclonal [clone OTI1A1] (IgG1) to Human MAPK9 / JNK2
Mouse, Dog, Rat, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
100µl 1mg/ml  $345.00
IHC of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-MAPK9 mouse monoclonal antibody.
IHC of paraffin-embedded Human pancreas tissue using anti-MAPK9 mouse monoclonal antibody.

MAPK9 / JNK2 Antibody (clone OTI1A1, Carrier-free) LS-C797684
Mouse Monoclonal [clone OTI1A1] (IgG1) to Human MAPK9 / JNK2
Mouse, Dog, Rat, Human, Monkey
IF, IHC, WB
Unconjugated, Carrier-free
100µg  $395.00
IHC of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-MAPK9 mouse monoclonal antibody.
IHC of paraffin-embedded Human pancreas tissue using anti-MAPK9 mouse monoclonal antibody.

MAPK9 / JNK2 Antibody LS-C487867
Rabbit Polyclonal to Human MAPK9 / JNK2
Human
ELISA, ICC, IF, IHC, IHC-P, IP, WB
Unconjugated
50µl  $275.00; 100µl  $355.00

MAPK9 / JNK2 Antibody LS-C806149
Rabbit Polyclonal (IgG) to Human MAPK9 / JNK2
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µl 1mg/ml  $325.00; 200µl 1mg/ml  $375.00
Immunohistochemistry Image
Immunofluorescence Image

IHC-plus™ MAPK9 / JNK2 Antibody (C-Terminus) LS-B1828
Rabbit Polyclonal to Human MAPK9 / JNK2
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µg 0.5mg/ml  $425.00
Anti-MAPK9 / JNK2 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.

MAPK9 / JNK2 Antibody LS-C487863
Rabbit Polyclonal to Human MAPK9 / JNK2
Human
ELISA, ICC, IF, IP, WB
Unconjugated
50µl  $275.00; 100µl  $355.00

MAPK9 / JNK2 Antibody (Thr183/) LS-C190216
Rabbit Polyclonal (IgG) to Human MAPK9 / JNK2
Mouse, Rat, Human
ICC, IHC, IP, WB
Unconjugated
100µg  $590.00

MAPK9 / JNK2 Antibody LS-C487864
Mouse Monoclonal to Human MAPK9 / JNK2
Human
Flo, ICC, IF
Unconjugated
50µl  $255.00; 100µl  $305.00; 200µl  $355.00

MAPK9 / JNK2 Antibody (clone OTI2H3) LS-C174557
Mouse Monoclonal [clone OTI2H3] (IgG1) to Human MAPK9 / JNK2
Human
IHC, IHC-P, WB
Unconjugated
100µl 1mg/ml  $345.00
IHC of paraffin-embedded Human breast tissue using anti-MAPK9 mouse monoclonal antibody.
IHC of paraffin-embedded Human pancreas tissue using anti-MAPK9 mouse monoclonal antibody.

MAPK9 / JNK2 Antibody (clone OTI2H3, Carrier-free) LS-C787902
Mouse Monoclonal [clone OTI2H3] (IgG1) to Human MAPK9 / JNK2
Human
IHC, WB
Unconjugated, Carrier-free
100µg  $395.00
IHC of paraffin-embedded Human breast tissue using anti-MAPK9 mouse monoclonal antibody.
IHC of paraffin-embedded Human pancreas tissue using anti-MAPK9 mouse monoclonal antibody.

MAPK9 / JNK2 Antibody (clone OTI2D11) LS-C174560
Mouse Monoclonal [clone OTI2D11] (IgG1) to Human MAPK9 / JNK2
Mouse, Dog, Rat, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100µl 1mg/ml  $345.00
IHC of paraffin-embedded Human pancreas tissue using anti-MAPK9 mouse monoclonal antibody.
IHC of paraffin-embedded Human tonsil using anti-MAPK9 mouse monoclonal antibody.

MAPK9 / JNK2 Antibody (clone OTI2D11, Carrier-free) LS-C787905
Mouse Monoclonal [clone OTI2D11] (IgG1) to Human MAPK9 / JNK2
Mouse, Dog, Rat, Human, Monkey
IHC, WB
Unconjugated, Carrier-free
100µg  $395.00
IHC of paraffin-embedded Human pancreas tissue using anti-MAPK9 mouse monoclonal antibody.
IHC of paraffin-embedded Human tonsil using anti-MAPK9 mouse monoclonal antibody.

MAPK9 / JNK2 Antibody LS-C767697
Rabbit Polyclonal (IgG) to Human MAPK9 / JNK2
Mouse, Human
IF, IHC, WB
Unconjugated
60µl 1mg/ml  $235.00; 120µl 1mg/ml  $295.00; 200µl 1mg/ml  $395.00

MAPK9 / JNK2 Antibody (aa206-233) LS-C329815
Rabbit Polyclonal (IgG) to Mouse MAPK9 / JNK2
Mouse, Human
ELISA, IHC, WB
Unconjugated
200µl  $590.00

MAPK9 / JNK2 Antibody LS-C666538
Rabbit Polyclonal (IgG) to Human MAPK9 / JNK2
Human
ELISA, IF, WB
Unconjugated
100µg  $335.00

MAPK9 / JNK2 Antibody LS-C767694
Rabbit Polyclonal (IgG) to Human MAPK9 / JNK2
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20µl 0.4mg/ml  $205.00; 60µl 0.4mg/ml  $235.00; 120µl 0.4mg/ml  $295.00; 200µl 0.4mg/ml  $395.00
Showing 1-25 of 72 results

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If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).