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MAPK4 / ERK4
mitogen-activated protein kinase 4
Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle.
| Gene Name: | mitogen-activated protein kinase 4 |
| Family/Subfamily: | Protein Kinase , MAPK |
| Synonyms: | MAPK4, ERK-4, Erk3-related, Erk4, MAP kinase isoform p63, PRKM4, RMNK2, MAP kinase 4, ERK3, MAPK 4, p63-MAPK, p63MAPK |
| Target Sequences: | NM_002747 NP_002738.2 P31152 |
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