MAPK13 / p38delta

mitogen-activated protein kinase 13

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells.

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Products

Proteins (10)

Type

Over-Expression Lysate (2)

Recombinant (8)

Target

MAPK13 / p38delta (10)

Publications

No (10)

Tag

GST (2)

GST, N-terminus (2)

His (1)

His-SUMO (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (9)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (2)

Insect Cells (1)

Wheat Germ Extract (3)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (1)

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Human MAPK13 / p38delta Protein (Recombinant His-SUMO) (Full Length) - LS-G20948

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

58.06 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human MAPK13 / p38delta Protein (Recombinant His-T7) (aa1-365) - LS-G25327

Source:

E. coli

Tag:

His-T7

Molecular Weight:

45.8 kDa

Price:

10 µg/$280; 50 µg/$432; 100 µg/$692; 200 µg/$865; 1 mg/$1,966; 500 µg/$1,510; 5 mg/$3,025; 2 mg/$2,153

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Human MAPK13 / p38delta Protein (Recombinant GST) (Full Length) - LS-G29921

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

65.78 kDa

Price:

10 µg/$479; 25 µg/$670

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Human MAPK13 / p38delta Protein (Recombinant GST) (Full Length) - LS-G29922

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

65.89 kDa

Price:

10 µg/$479; 25 µg/$670

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Human MAPK13 / p38delta Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67523

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

41.9 kDa

Price:

20 µg/$1,107

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Human MAPK13 / p38delta Protein (Recombinant GST, N-terminus) (aa251-365) - LS-G59750

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human MAPK13 / p38delta Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80060

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

41.9 kDa

Price:

20 µg/$150

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MAPK13 / p38delta Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99856

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

41.9 kDa

Price:

100 µg/$494

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Human MAPK13 / p38delta Protein (Recombinant GST, N-terminus) (Met1-Leu365) - LS-G139929

Source:

Insect Cells

Tag:

GST, N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

68.4 kDa

Price:

50 µg/$502

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Human MAPK13 / p38delta Protein (Recombinant His) - LS-G1511

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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