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MAPK13 / p38delta

mitogen-activated protein kinase 13

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells.

Gene Name: mitogen-activated protein kinase 13
Family/Subfamily: Protein Kinase , MAPK
Synonyms: MAPK13, MAPK-13, MAPK 13, p38delta, PRKM13, SAPK4, Serk 4, MAP kinase 13, MAP kinase p38 delta
Target Sequences: NM_002754 NP_002745.1 O15264

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Products
Proteins (11)
Over-Expression Lysate (2)
Recombinant (9)
MAPK13 / p38delta (11)
No (11)
GST (2)
GST, N-terminus (2)
His (1)
His-SUMO (1)
His-T7 (1)
Myc-DDK (Flag) (3)
Human (10)
293T Cells (1)
E. coli (3)
HEK 293 Cells (2)
Insect Cells (2)
Wheat Germ Extract (3)
Purified (3)
Low endotoxin level (1)
Biologically active (1)
MAPK13 / p38delta Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$469; 25 µg/$630
MAPK13 / p38delta Protein - Purified recombinant protein MAPK13 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
41.9 kDa
20 µg/$1,005
MAPK13 / p38delta Protein
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E. coli
His-SUMO
58.06 kD
1 mg/$1,207; 100 µg/$408; 20 µg/$311
MAPK13 / p38delta Protein - Recombinant Mitogen Activated Protein Kinase 13 By SDS-PAGE
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E. coli
His-T7
45.8 kDa
10 µg/$270; 50 µg/$412; 100 µg/$660; 200 µg/$824; 1 mg/$1,853; 500 µg/$1,376; 5 mg/$4,001
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Insect Cells
None
Biologically active
~71 kDa
10 µg/$481
MAPK13 / p38delta Protein - 12.5% SDS-PAGE of human MAPK13 stained with Coomassie Blue
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Wheat Germ Extract
GST
65.78 kDa
10 µg/$469; 25 µg/$630
MAPK13 / p38delta Protein - 12.5% SDS-PAGE of human MAPK13 stained with Coomassie Blue
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Wheat Germ Extract
GST
65.89 kDa
10 µg/$469; 25 µg/$630
MAPK13 / p38delta Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
41.9 kDa
100 µg/$458
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293T Cells
Myc-DDK (Flag)
41.9 kDa
20 µg/$130
MAPK13 / p38delta Protein
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E. coli
His
100 µg/$351; 500 µg/$694; 20 µg/$249
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Insect Cells
GST, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
68.4 kDa
20 µg/$420; 50 µg/$492
Viewing 1-11 of 11 product results


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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).