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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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MAP4K4

mitogen-activated protein kinase kinase kinase kinase 4

MAP4K4 is a MSN protein kinase. The protein has a structure similar to other GCK (Group I) kinases and contains two consensus SH3 binding motifs, which have been shown to interact with the SH3 domains of the SH2/SH3 adapter protein Nck. NIK can be activated by tumor necrosis factor (TNF)-alpha. Activated NIK has been shown to activate c-Jun N-terminal kinase (JNK) and to bind and activate the plasma membrane Na-H exchanger NHE1. In NIK(-/-) mice, mesodermal and endodermal cells of the primitive streak fail to migrate to their correct location, and embryos die between embryonic day (E) 9.5 and E10.5. At least three protein isoforms have been reported.

Gene Name: mitogen-activated protein kinase kinase kinase kinase 4
Family/Subfamily: Protein Kinase , MSN
Synonyms: MAP4K4, HGK, HPK/GCK-like kinase HGK, KIAA0687, Misshapen, NIK, Nck-interacting kinase, HPK/GCK-like kinase, Ste20 group protein kinase HGK, MEKKK 4, MEKKK4, Zc1, FLH21957, MEK kinase kinase 4
Target Sequences: NM_145686 NP_663719.2 O95819

Publications (1)

1
Inflexibility in intramuscular triglyceride fractional synthesis distinguishes prediabetes from obesity in humans. Perreault L, Bergman BC, Hunerdosse DM, Playdon MC, Eckel RH. Obesity (Silver Spring, Md.). 2010 18:1524-31. [PubMed:20035285] [PMC:PMC3232014]

Filtered by: None
Target
MAP4K4 (45)
Reactivity
Human (45)
Mouse (19)
Rat (4)
Bat (4)
Bovine (4)
Chicken (4)
Chimpanzee (3)
Dog (4)
Gibbon (3)
Guinea pig (4)
Horse (4)
Monkey (1)
Pig (4)
Rabbit (4)
Xenopus (4)
Application
IHC (9)
IHC-P (6)
WB (37)
Flo (7)
DB (7)
ELISA (28)
ICC (1)
IF (5)
IP (2)
Peptide-ELISA (1)
Host
rabbit (39)
mouse (6)
Isotype
IgG (31)
IgG1 (5)
IgG1,k (1)
Clonality
monoclonal mc (7)
polyclonal pc (38)
Clone
3C7B5 (2)
4A5 (1)
4H9E7 (2)
Format
AP Conjugated (3)
APC Conjugated (3)
Azide-free (3)
Biotin Conjugated (4)
FITC Conjugated (4)
HRP Conjugated (4)
PE Conjugated (3)
Unconjugated (24)
Epitope
aa506-534 (8)
aa618-649 (7)
pSer629 (7)
aa287-336 (4)
Amino Acid: 400-500 (2)
aa550-600 (2)
380-460 aa, Internal (1)
Ala553 (1)
Arg430 (1)
aa406-455 (1)
aa850-900 (1)
aa931-947 (1)
Publications
No (45)
Showing 1-25 of 45 results

IHC-plus™ MAP4K4 Antibody (aa287-336) LS-B5815
Rabbit Polyclonal to Human MAP4K4
Xenopus, Chicken, Bovine, Rat, Pig, Horse, Rabbit, Mouse, Dog, Guinea pig, Bat, Human
IHC, IHC-P, WB
Unconjugated
100µl  $485.00
Anti-MAP4K4 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
MAP4K4 antibody Western blot of Fetal Small Intestine lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

MAP4K4 Antibody (aa287-336, Biotin) LS-C451968
Rabbit Polyclonal to Human MAP4K4
Xenopus, Chicken, Bovine, Rat, Rabbit, Mouse, Dog, Guinea pig, Bat, Pig, Horse, Gibbon, Chimpanzee, Human
IHC, IHC-P, WB
Biotin Conjugated
100µl 1mg/ml  $405.00
Anti-MAP4K4 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
MAP4K4 antibody Western blot of Fetal Small Intestine lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

MAP4K4 Antibody (aa287-336, FITC) LS-C451970
Rabbit Polyclonal to Human MAP4K4
Xenopus, Chicken, Bovine, Rat, Rabbit, Mouse, Dog, Guinea pig, Bat, Pig, Horse, Gibbon, Chimpanzee, Human
IHC, IHC-P, WB
FITC Conjugated
100µl 1mg/ml  $405.00
Anti-MAP4K4 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
MAP4K4 antibody Western blot of Fetal Small Intestine lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

IHC-plus™ MAP4K4 Antibody (aa931-947) LS-B712
Rabbit Polyclonal to Human MAP4K4
Human
IHC, IHC-P, WB
Unconjugated
50µg 0.5mg/ml  $505.00
Anti-MAP4K4 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.

MAP4K4 Antibody (aa406-455) LS-C118740
Rabbit Polyclonal (IgG) to Human MAP4K4
Mouse, Human
IF, Peptide-ELISA, WB
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
Immunofluorescence analysis of A549 cells, using MEKKK 4 Antibody. The picture on the right is blocked with the synthesized peptide.
Western blot analysis of lysates from HUVEC and COLO cells, using MEKKK 4 Antibody. The lane on the right is blocked with the synthesized peptide.

MAP4K4 Antibody (clone 4A5) LS-C105080
Mouse Monoclonal [clone 4A5] (IgG1,k) to Human MAP4K4
Human
ELISA, WB
Unconjugated
100µg  $365.00
MAP4K4 monoclonal antibody (M07), clone 4A5 Western blot of MAP4K4 expression in K-562.
Detection limit for recombinant GST tagged MAP4K4 is approximately 0.03 ng/ml as a capture antibody.

MAP4K4 Antibody (Ala553) LS-C191011
Rabbit Monoclonal (IgG) to Human MAP4K4
Mouse, Human, Monkey
WB
Unconjugated
100µl  $530.00

IHC-plus™ MAP4K4 Antibody LS-B14381
Rabbit Polyclonal (IgG) to Human MAP4K4
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50µl  $425.00
Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
Western blot analysis using MAP4K4 antibody.

MAP4K4 Antibody LS-C416145
Rabbit Polyclonal to Human MAP4K4
Mouse, Human
ICC, IF, WB
Unconjugated
100µg  $305.00
Western blot of HUVEC cell lysate using MEKKK 4 Antibody

MAP4K4 Antibody (380-460 aa, Internal) LS-C383923
Rabbit Polyclonal (IgG) to Human MAP4K4
Mouse, Human
ELISA, IF, WB
Unconjugated
50µl 1mg/ml  $235.00; 100µl 1mg/ml  $265.00; 200µl 1mg/ml  $335.00
Western blot of HGK antibody

MAP4K4 Antibody LS-C666634
Rabbit Polyclonal (IgG) to Human MAP4K4
Human
ELISA, IHC, WB
Unconjugated
100µg  $335.00

MAP4K4 Antibody (aa618-649) LS-C323338
Rabbit Polyclonal (IgG) to Human MAP4K4
Human
ELISA, Flo, WB
Unconjugated
200µl  $590.00

MAP4K4 Antibody (aa618-649, Biotin) LS-C215972
Rabbit Polyclonal (IgG) to Human MAP4K4
Human
ELISA, Flo, WB
Biotin Conjugated
200µl  $740.00

MAP4K4 Antibody (aa618-649, FITC) LS-C215974
Rabbit Polyclonal (IgG) to Human MAP4K4
Human
ELISA, Flo, WB
FITC Conjugated
200µl  $740.00

MAP4K4 Antibody (aa618-649, AP) LS-C215970
Rabbit Polyclonal (IgG) to Human MAP4K4
Human
ELISA, Flo, WB
AP Conjugated
200µl  $740.00

MAP4K4 Antibody (aa618-649, APC) LS-C215971
Rabbit Polyclonal (IgG) to Human MAP4K4
Human
ELISA, Flo, WB
APC Conjugated
200µl  $740.00

MAP4K4 Antibody (aa618-649, Azide-free, HRP) LS-C215973
Rabbit Polyclonal (IgG) to Human MAP4K4
Human
ELISA, Flo, WB
HRP Conjugated, Azide-free
200µl  $740.00

MAP4K4 Antibody (aa618-649, PE) LS-C215975
Rabbit Polyclonal (IgG) to Human MAP4K4
Human
ELISA, Flo, WB
PE Conjugated
200µl  $740.00

MAP4K4 Antibody LS-C800554
Rabbit Polyclonal (IgG) to Human MAP4K4
Mouse, Human
ELISA, IF, WB
Unconjugated
100µl 1mg/ml  $325.00; 200µl 1mg/ml  $375.00
Immunofluorescence Image
Western blot Image

MAP4K4 Antibody (aa550-600) LS-C288299
Rabbit Polyclonal (IgG) to Human MAP4K4
Human
IHC, IP, WB
Unconjugated
100µl 1mg/ml  $395.00
Detection of Human MAP4K4/HGK by Immunohistochemistry. Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-MAP4K4/HGK used at a dilution of 1:1000 (1 ug/ml). Detection: DAB.

MAP4K4 Antibody (Arg430) LS-C176891
Rabbit Polyclonal to Human MAP4K4
Mouse, Human
IF, WB
Unconjugated
100µl  $345.00
Western blot of HGK (R430) pAb in extracts from HUVEC cells.

MAP4K4 Antibody (aa506-534) LS-C322839
Rabbit Polyclonal (IgG) to Mouse MAP4K4
Mouse, Human
ELISA, WB
Unconjugated
200µl  $590.00

MAP4K4 Antibody LS-C802060
Mouse Monoclonal (IgG1) to Human MAP4K4
Human
ELISA, WB
Unconjugated
50µl 1mg/ml  $315.00; 100µl 1mg/ml  $375.00; 200µl 1mg/ml  $435.00

MAP4K4 Antibody (clone 4H9E7) LS-C108875
Mouse Monoclonal [clone 4H9E7] (IgG1) to Human MAP4K4
Human
ELISA, WB
Unconjugated
100µl  $345.00
Western blot using MAP4K4 mouse monoclonal antibody against truncated Trx-MAP4K4 recombinant protein (1), MBP-MAP4K4 (aa300-400) recombinant protein (2) and MAP4K4(aa194-436)-hIgGFc transfected CH0-K1 cell lysate(3).

MAP4K4 Antibody (clone 3C7B5) LS-C108876
Mouse Monoclonal [clone 3C7B5] (IgG1) to Human MAP4K4
Human
ELISA, WB
Unconjugated
100µl  $375.00
Western blot using MAP4K4 mouse monoclonal antibody against truncated Trx-MAP4K4 recombinant protein (1), MBP-MAP4K4 (aa300-400) recombinant protein (2) and MAP4K4(aa194-436)-hIgGFc transfected CH0-K1 cell lysate(3).
Showing 1-25 of 45 results

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If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).