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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Infectious Disease
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MAP4K4

mitogen-activated protein kinase kinase kinase kinase 4

MAP4K4 is a MSN protein kinase. The protein has a structure similar to other GCK (Group I) kinases and contains two consensus SH3 binding motifs, which have been shown to interact with the SH3 domains of the SH2/SH3 adapter protein Nck. NIK can be activated by tumor necrosis factor (TNF)-alpha. Activated NIK has been shown to activate c-Jun N-terminal kinase (JNK) and to bind and activate the plasma membrane Na-H exchanger NHE1. In NIK(-/-) mice, mesodermal and endodermal cells of the primitive streak fail to migrate to their correct location, and embryos die between embryonic day (E) 9.5 and E10.5. At least three protein isoforms have been reported.

Gene Name: mitogen-activated protein kinase kinase kinase kinase 4
Family/Subfamily: Protein Kinase , MSN
Synonyms: MAP4K4, HGK, HPK/GCK-like kinase HGK, KIAA0687, Misshapen, NIK, Nck-interacting kinase, HPK/GCK-like kinase, Ste20 group protein kinase HGK, MEKKK 4, MEKKK4, Zc1, FLH21957, MEK kinase kinase 4
Target Sequences: NM_145686 NP_663719.2 O95819

Publications (1)

1
Inflexibility in intramuscular triglyceride fractional synthesis distinguishes prediabetes from obesity in humans. Perreault L, Bergman BC, Hunerdosse DM, Playdon MC, Eckel RH. Obesity (Silver Spring, Md.). 2010 18:1524-31. [PubMed:20035285] [PMC:PMC3232014]


MAP4K4 Antibody - Anti-MAP4K4 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal to Human MAP4K4
Xenopus, Chicken, Bovine, Rat, Pig, Horse, Rabbit, Mouse, Dog, Guinea pig, Bat, Human
IHC, IHC-P, WB
Unconjugated
100µl   $485.00
MAP4K4 Antibody - Anti-MAP4K4 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
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Rabbit Polyclonal to Human MAP4K4
Human
IHC, IHC-P, WB
Unconjugated
50µg   0.5mg/ml   $515.00
MAP4K4 Antibody - Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Rabbit Polyclonal (IgG) to Human MAP4K4
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50µl   $425.00
MAP4K4 Antibody - Immunofluorescence analysis of A549 cells, using MEKKK 4 Antibody. The picture on the right is blocked with the synthesized peptide.
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Rabbit Polyclonal (IgG) to Human MAP4K4
Mouse, Human
IF, Peptide-ELISA, WB
Unconjugated
50µl   1mg/ml   $265.00; 100µl   1mg/ml   $325.00
MAP4K4 Antibody - MAP4K4 monoclonal antibody (M07), clone 4A5 Western blot of MAP4K4 expression in K-562.
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Mouse Monoclonal [clone 4A5] (IgG1,k) to Human MAP4K4
Human
ELISA, WB
Unconjugated
100µg   $365.00
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Rabbit Monoclonal (IgG) to Human MAP4K4
Mouse, Human, Monkey
WB
Unconjugated
100µl   $530.00
MAP4K4 Antibody - Western blot of HUVEC cell lysate using MEKKK 4 Antibody
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Rabbit Polyclonal to Human MAP4K4
Mouse, Human
ICC, IF, WB
Unconjugated
50µg   50µl   1mg/ml   $255.00; 100µg   100µl   1mg/ml   $305.00
MAP4K4 Antibody - Western blot of HGK antibody
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Rabbit Polyclonal (IgG) to Human MAP4K4
Mouse, Human
ELISA, IF, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
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Rabbit Polyclonal (IgG) to Human MAP4K4
Human
ELISA, IHC, WB
Unconjugated
100µg   $375.00
Select
Rabbit Polyclonal (IgG) to Human MAP4K4
Human
ELISA, Flo, WB
Unconjugated
200µl   $590.00
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Rabbit Polyclonal (IgG) to Human MAP4K4
Human
ELISA, Flo, WB
Biotin Conjugated
200µl   $740.00
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Rabbit Polyclonal (IgG) to Human MAP4K4
Human
ELISA, Flo, WB
FITC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human MAP4K4
Human
ELISA, Flo, WB
AP Conjugated
200µl   $740.00
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Rabbit Polyclonal (IgG) to Human MAP4K4
Human
ELISA, Flo, WB
HRP Conjugated, Azide-free
200µl   $740.00
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Rabbit Polyclonal (IgG) to Human MAP4K4
Human
ELISA, Flo, WB
PE Conjugated
200µl   $740.00
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Rabbit Polyclonal (IgG) to Human MAP4K4
Human
ELISA, Flo, WB
APC Conjugated
200µl   $740.00
MAP4K4 Antibody - Peptide - + Immunofluorescence analysis of A549 cells, using MEKKK 4 antibody.
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Rabbit Polyclonal (IgG) to Human MAP4K4
Mouse, Human
ELISA, IF, WB
Unconjugated
100µg   $305.00
MAP4K4 Antibody - Staining HeLa cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody, diluted at 1/600, was used as secondary antibody.
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Rabbit Polyclonal (IgG) to Human MAP4K4
Mouse, Human
ELISA, IF, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
MAP4K4 Antibody - Detection of Human MAP4K4/HGK by Immunohistochemistry. Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-MAP4K4/HGK used at a dilution of 1:1000 (1 ug/ml). Detection: DAB.
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Rabbit Polyclonal (IgG) to Human MAP4K4
Human
IHC, IP, WB
Unconjugated
100µl   1mg/ml   $405.00
MAP4K4 Antibody - Western blot of HGK (R430) pAb in extracts from HUVEC cells.
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Rabbit Polyclonal to Human MAP4K4
Mouse, Human
IF, WB
Unconjugated
100µl   $345.00
Select
Rabbit Polyclonal (IgG) to Mouse MAP4K4
Mouse, Human
ELISA, WB
Unconjugated
200µl   $590.00
Select
Mouse Monoclonal (IgG1) to Human MAP4K4
Human
ELISA, WB
Unconjugated
50µl   1mg/ml   $315.00; 100µl   1mg/ml   $375.00; 200µl   1mg/ml   $435.00
MAP4K4 Antibody - Western blot using MAP4K4 mouse monoclonal antibody against truncated Trx-MAP4K4 recombinant protein (1), MBP-MAP4K4 (aa300-400) recombinant protein (2) and MAP4K4(aa194-436)-hIgGFc transfected CH0-K1 cell lysate(3).
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Mouse Monoclonal [clone 3C7B5] (IgG1) to Human MAP4K4
Human
ELISA, WB
Unconjugated
100µl   $375.00
MAP4K4 Antibody - Western blot using MAP4K4 mouse monoclonal antibody against truncated Trx-MAP4K4 recombinant protein (1), MBP-MAP4K4 (aa300-400) recombinant protein (2) and MAP4K4(aa194-436)-hIgGFc transfected CH0-K1 cell lysate(3).
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Mouse Monoclonal [clone 4H9E7] (IgG1) to Human MAP4K4
Human
ELISA, WB
Unconjugated
100µl   $345.00
MAP4K4 Antibody - Western Blot (WB) analysis using HGK Monoclonal Antibody against truncated Trx-HGK recombinant protein (1), MBP-HGK (aa300-400) recombinant protein (2) and HGK(aa194-436)-hIgGFc transfected CH0-K1 cell lysate(3).
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Mouse Monoclonal (IgG1) to Human MAP4K4
Human
ELISA, WB
Unconjugated
100µl   $345.00
Viewing 1-25 of 48 products



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).