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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
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MAP4K3 / GLK
mitogen-activated protein kinase kinase kinase kinase 3
GLK, a KHS protein kinase, activates the c-Jun N-terminal kinase (JNK) signaling pathway. Evidence suggests that it functions upstream of MEKK1. The protein has a structure similar to other GCK (Group I) kinases and contains an endophilin consensus-binding sequence PPRPPPPR, which has been shown to bind the SH3 domain of endophilin I in rat. GLK is activated by UV radiation and the proinflammatory cytokine tumor necrosis factor (TNF)-alpha.
| Gene Name: | mitogen-activated protein kinase kinase kinase kinase 3 |
| Family/Subfamily: | Protein Kinase , KHS |
| Synonyms: | MAP4K3, MEK kinase kinase 3, RAB8IPL1, MEKKK 3, MEKKK3, GCK-like kinase, GLK, MAPKKKK3 |
| Target Sequences: | NM_003618 NP_003609.2 Q8IVH8 |
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