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MAP3K2 / MEKK2
mitogen-activated protein kinase kinase kinase 2
MEKK2, a MAP3K type protein kinase, is a member of MAP kinase signaling pathways. The protein contains a C-terminal protein kinase domain and a non-catalytic N-terminal domain. MEKK2 has been shown to regulate both JNK and ERK cascades by phosphorylating and activating either MKK4/MAP2K4 or MEK1/MAP2K1, respectively. Additionally, MEKK2 has been shown to directly phosphorylate and activate Ikappa B kinases (IKKs) of the immune and inflammatory response NF-kappa B signaling pathway and to bind and activate protein kinase C-related kinase 2. MEKK2 (-/-) embryonic stem cell-derived mast cells demonstrate that this protein is required for cytokine production and receptor-mediated stimulation of JNK.
| Gene Name: | mitogen-activated protein kinase kinase kinase 2 |
| Family/Subfamily: | Protein Kinase , MAP3K |
| Synonyms: | MAP3K2, MAP/ERK kinase kinase 2, MAPK/ERK kinase kinase 2, MAPKKK2, MEK kinase 2, MEKK 2, MEKK2, MEKK2B |
| Target Sequences: | NM_006609 NP_006600.3 Q9Y2U5 |
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