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MAP3K10 / MLK2 is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis.
Gene Name: | mitogen-activated protein kinase kinase kinase 10 |
Family/Subfamily: | Protein Kinase , MLK(MAP3K) |
Synonyms: | MAP3K10, MEKK10, MKN28 kinase, Protein kinase MST, Mixed lineage kinase 2, MLK2, MST |
Target Sequences: | NM_002446 NP_002437.2 Q02779 |
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