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MAP2K1 / MKK1 / MEK1

mitogen-activated protein kinase kinase 1

Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis.

Gene Name: mitogen-activated protein kinase kinase 1
Family/Subfamily: Protein Kinase , MAP2K
Synonyms: MAP2K1, ERK activator kinase 1, MAPK/ERK kinase 1, MAPKK 1, MKK1, PRKMK1, MEK 1, MAP kinase kinase 1, MAPKK1, MEK1
Target Sequences: NM_002755 NP_002746.1 Q02750

☰ Filters
Antibodies (288)
cDNAs (30)
ELISA Kits (17)
Proteins (12)
cDNA Clone (2)
Cell-Based (1)
Cell-Based Phosphorylation (3)
Custom (7)
Expression-Ready ORF Clone (28)
Over-Expression Lysate (4)
Primary (288)
Recombinant (8)
Sandwich (5)
Sandwich CLIA (1)
MAP2K1 / MKK1 / MEK1 (347)
Human (288)
Mouse (222)
Rat (194)
Bat (5)
Bovine (27)
Chicken (10)
Chimpanzee (6)
Dog (84)
Drosophila (2)
Gibbon (3)
Goat (1)
Guinea pig (9)
Hamster (12)
Horse (12)
Monkey (78)
Pig (20)
Porcine (1)
Primate (1)
Rabbit (24)
Sheep (2)
Xenopus (18)
Zebrafish (5)
IHC (153)
IHC-P (55)
WB (270)
Flo (2)
DB (8)
ELISA (93)
FLISA (3)
ICC (7)
IF (92)
IP (22)
Peptide-ELISA (8)
rabbit (184)
mouse (103)
goat (1)
Product Group
IHCPlus (3)
IgG (124)
IgG1 (34)
IgG1,k (11)
IgG2a (25)
IgG2a,k (1)
IgG2b (32)
monoclonal mc (105)
polyclonal pc (183)
131 (1)
13B6.G12 (8)
1678CT373.38.18 (1)
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3D9 (1)
4A5 (1)
OTI1A10 (2)
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aa269-296 (8)
aa54-369 (8)
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230-310 aa (4)
aa353-367 (4)
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240-320 aa (2)
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330-410 aa (1)
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Thr286 (1)
aa1-12 (1)
aa200-250 (1)
aa244-293 (1)
aa252-301 (1)
aa261-310 (1)
aa264-313 (1)
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pSer297 (1)
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MAP2K1 / MKK1 / MEK1 Antibody - Anti-MAP2K1 / MEK1 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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MAP2K1 / MKK1 / MEK1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Xenopus, Rat, Mouse, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µg/$460
MAP2K1 / MKK1 / MEK1 Antibody - Immunohistochemical analysis of MKK1 staining in human prostate cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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MAP2K1 / MKK1 / MEK1 Rabbit anti-Human Polyclonal (Internal) Antibody
Rabbit, Mouse, Bovine, Rat, Pig, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100 µl/$289
MAP2K1 / MKK1 / MEK1 Antibody - Immunofluorescence staining of MEK1 in NIH/3T3 cells. Cells were fixed with 4% PFA, permeabilzed with 0.1% Triton X-100 in PBS, blocked with 10% serum, and incubated with rabbit anti-Mouse MEK1 monoclonal antibody (dilution ratio 1:60) at 4°C overnight. Then cells were stained with the Alexa Fluor 488-conjugated Goat Anti-rabbit IgG secondary antibody (green) and counterstained with DAPI (blue). Positive staining was localized to Cytoplasm.
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MAP2K1 / MKK1 / MEK1 Rabbit anti-Mouse Monoclonal (Preservative Free) (131) Antibody
Mouse
ICC, IF, WB
Unconjugated, Preservative Free
50 µl/$290; 100 µl/$350
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MAP2K1 / MKK1 / MEK1 Mouse anti-Human Monoclonal (pSer218/Ser222) Antibody
Mouse, Dog, Human
ELISA, WB
Unconjugated
100 µg/$820
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MAP2K1 / MKK1 / MEK1 Mouse anti-Mouse Monoclonal Antibody
Mouse
IP, WB
Unconjugated
100 µg/$660
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MAP2K1 / MKK1 / MEK1 Rabbit anti-Human Monoclonal Antibody
Mouse, Rat, Human, Monkey
ELISA, WB
Unconjugated
100 µl/$562
MAP2K1 / MKK1 / MEK1 Antibody - Immunohistochemical staining of paraffin-embedded colon tissue using anti-MAP2K1 mouse monoclonal antibody. (Dilution 1:50).
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MAP2K1 / MKK1 / MEK1 Mouse anti-Human Monoclonal (OTI1C1) Antibody
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$390
MAP2K1 / MKK1 / MEK1 Antibody - Immunohistochemical staining of paraffin-embedded colon tissue using anti-MAP2K1 mouse monoclonal antibody. (Dilution 1:50).
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MAP2K1 / MKK1 / MEK1 Mouse anti-Human Monoclonal (OTI1F5) Antibody
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$390
MAP2K1 / MKK1 / MEK1 Antibody - IHC of paraffin-embedded Carcinoma of Human lung tissue using anti-MAP2K1 mouse monoclonal antibody.
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MAP2K1 / MKK1 / MEK1 Mouse anti-Human Monoclonal (OTI2H3) Antibody
Mouse, Dog, Rat, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$390
MAP2K1 / MKK1 / MEK1 Antibody - IHC of paraffin-embedded Human pancreas tissue using anti-MAP2K1 mouse monoclonal antibody.
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MAP2K1 / MKK1 / MEK1 Mouse anti-Human Monoclonal (OTI3B4) Antibody
Mouse, Dog, Rat, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$390
MAP2K1 / MKK1 / MEK1 Antibody - IHC of paraffin-embedded Carcinoma of Human lung tissue using anti-MAP2K1 mouse monoclonal antibody.
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MAP2K1 / MKK1 / MEK1 Mouse anti-Human Monoclonal (OTI2B2) Antibody
Mouse, Dog, Rat, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$390
MAP2K1 / MKK1 / MEK1 Antibody - IHC of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-MAP2K1 mouse monoclonal antibody.
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MAP2K1 / MKK1 / MEK1 Mouse anti-Human Monoclonal (OTI2A1) Antibody
Mouse, Dog, Rat, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$390
MAP2K1 / MKK1 / MEK1 Antibody - IHC of paraffin-embedded Human pancreas tissue using anti-MAP2K1 mouse monoclonal antibody.
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MAP2K1 / MKK1 / MEK1 Mouse anti-Human Monoclonal (OTI2A9) Antibody
Mouse, Dog, Rat, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$390
MAP2K1 / MKK1 / MEK1 Antibody - IHC of paraffin-embedded Human pancreas tissue using anti-MAP2K1 mouse monoclonal antibody.
Select
MAP2K1 / MKK1 / MEK1 Mouse anti-Human Monoclonal (OTI4H8) Antibody
Mouse, Dog, Rat, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$390
MAP2K1 / MKK1 / MEK1 Antibody - IHC of paraffin-embedded Human lung tissue using anti-MAP2K1 mouse monoclonal antibody.
Select
MAP2K1 / MKK1 / MEK1 Mouse anti-Human Monoclonal (OTI3H5) Antibody
Mouse, Dog, Rat, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$390
MAP2K1 / MKK1 / MEK1 Antibody - IHC of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-MAP2K1 mouse monoclonal antibody.
Select
MAP2K1 / MKK1 / MEK1 Mouse anti-Human Monoclonal (OTI4F1) Antibody
Mouse, Dog, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$390
MAP2K1 / MKK1 / MEK1 Antibody - IHC of paraffin-embedded Human pancreas tissue using anti-MAP2K1 mouse monoclonal antibody.
Select
MAP2K1 / MKK1 / MEK1 Mouse anti-Human Monoclonal (OTI4E4) Antibody
Mouse, Dog, Rat, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$390
MAP2K1 / MKK1 / MEK1 Antibody - IHC of paraffin-embedded Human lung tissue using anti-MAP2K1 mouse monoclonal antibody.
Select
MAP2K1 / MKK1 / MEK1 Mouse anti-Human Monoclonal (OTI4B1) Antibody
Mouse, Dog, Rat, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$390
MAP2K1 / MKK1 / MEK1 Antibody - IHC of paraffin-embedded Human liver tissue using anti-MAP2K1 mouse monoclonal antibody.
Select
MAP2K1 / MKK1 / MEK1 Mouse anti-Human Monoclonal (OTI3H3) Antibody
Mouse, Dog, Rat, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$390
MAP2K1 / MKK1 / MEK1 Antibody - IHC of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-MAP2K1 mouse monoclonal antibody.
Select
MAP2K1 / MKK1 / MEK1 Mouse anti-Human Monoclonal (OTI2F1) Antibody
Mouse, Dog, Rat, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$390
MAP2K1 / MKK1 / MEK1 Antibody - IHC of paraffin-embedded Human Kidney tissue using anti-MAP2K1 mouse monoclonal antibody.
Select
MAP2K1 / MKK1 / MEK1 Mouse anti-Human Monoclonal (OTI2F12) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$390
MAP2K1 / MKK1 / MEK1 Antibody - IHC of paraffin-embedded Human Kidney tissue using anti-MAP2K1 mouse monoclonal antibody.
Select
MAP2K1 / MKK1 / MEK1 Mouse anti-Human Monoclonal (OTI7E2) Antibody
Mouse, Dog, Rat, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$390
MAP2K1 / MKK1 / MEK1 Antibody - IHC of paraffin-embedded Human Ovary tissue using anti-MAP2K1 mouse monoclonal antibody.
Select
MAP2K1 / MKK1 / MEK1 Mouse anti-Human Monoclonal (OTI6C6) Antibody
Mouse, Dog, Rat, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$390
MAP2K1 / MKK1 / MEK1 Antibody - IHC of paraffin-embedded Human Kidney tissue using anti-MAP2K1 mouse monoclonal antibody.
Select
MAP2K1 / MKK1 / MEK1 Mouse anti-Human Monoclonal (OTI7B1) Antibody
Mouse, Dog, Rat, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$390
MAP2K1 / MKK1 / MEK1 Antibody - IHC of paraffin-embedded Human Kidney tissue using anti-MAP2K1 mouse monoclonal antibody.
Select
MAP2K1 / MKK1 / MEK1 Mouse anti-Human Monoclonal (OTI8A6) Antibody
Mouse, Dog, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$390
Viewing 1-25 of 347 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).