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MAP1LC3A / LC3A

microtubule-associated protein 1 light chain 3 alpha

MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. The protein encoded by this gene is one of the light chain subunits and can associate with either MAP1A or MAP1B. Two transcript variants encoding different isoforms have been found for this gene. The expression of variant 1 is suppressed in many tumor cell lines, suggesting that may be involved in carcinogenesis.

Gene Name: microtubule-associated protein 1 light chain 3 alpha
Synonyms: MAP1LC3A, ATG8E, LC3, LC3A, MAP1BLC3, MAP1A/1B light chain 3 A, MAP1A/MAP1B LC3 A, MAP1A/MAP1B light chain 3 A, MAP1ALC3
Target Sequences: NM_032514 NP_115903.1 Q9H492

Publications (10)

1
Pathogenic lysosomal depletion in Parkinson's disease. Dehay B, Bov J, Rodrguez-Muela N, Perier C, Recasens A, Boya P, Vila M. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2010 30:12535-44. (WB; Mouse, Human) [PubMed:20844148]
2
Silica nanoconstruct cellular toleration threshold in vitro. Herd HL, Malugin A, Ghandehari H. Journal of controlled release : official journal of the Controlled Release Society. 2011 153:40-8. (WB; Mouse, Human) [PubMed:21342660] [PMC:PMC3197243]
3
Mouse knock-out of IOP1 protein reveals its essential role in mammalian cytosolic iron-sulfur protein biogenesis. Song D, Lee FS. The Journal of biological chemistry. 2011 286:15797-805. [PubMed:21367862] [PMC:PMC3091189] Related Antibodies: LS-C165694.
4
Overexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado-Joseph disease. Nascimento-Ferreira I, Santos-Ferreira T, Sousa-Ferreira L, Auregan G, Onofre I, Alves S, Dufour N, Colomer Gould VF, Koeppen A, Dglon N, Pereira de Almeida L. Brain : a journal of neurology. 2011 134:1400-15. [PubMed:21478185] Related Antibodies: LS-C165699.
5
Autophagy patterns and prognosis in uveal melanomas. Giatromanolaki AN, Charitoudis GS, Bechrakis NE, Kozobolis VP, Koukourakis MI, Foerster MH, Sivridis EL. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 2011 24:1036-45. [PubMed:21499230] Related Antibodies: LS-C159363.
6
Rab5 and class III phosphoinositide 3-kinase Vps34 are involved in hepatitis C virus NS4B-induced autophagy. Su WC, Chao TC, Huang YL, Weng SC, Jeng KS, Lai MM. Journal of virology. 2011 85:10561-71. [PubMed:21835792] [PMC:PMC3187495] Related Antibodies: LS-C158634.
7
Melatonin attenuates kainic acid-induced neurotoxicity in mouse hippocampus via inhibition of autophagy and -synuclein aggregation. Chang CF, Huang HJ, Lee HC, Hung KC, Wu RT, Lin AM. Journal of pineal research. 2012 52:312-21. (WB; Mouse) [PubMed:22212051]
8
Involvement of macroautophagy in multiple system atrophy and protein aggregate formation in oligodendrocytes. Schwarz L, Goldbaum O, Bergmann M, Probst-Cousin S, Richter-Landsberg C. Journal of molecular neuroscience : MN. 2012 47:256-66. (IHC; Human) [PubMed:22411133]
9
Autophagy induced by resveratrol prevents human prion protein-mediated neurotoxicity. Jeong JK, Moon MH, Bae BC, Lee YJ, Seol JW, Kang HS, Kim JS, Kang SJ, Park SY. Neuroscience research. 2012 73:99-105. (WB; Human) [PubMed:22465415]
10
Macroautophagy abnormality in essential tremor. Kuo SH, Tang G, Ma K, Babij R, Cortes E, Vonsattel JP, Faust PL, Sulzer D, Louis ED. PloS one. 2012 7:e53040. (WB; Human) [PubMed:23300858] [PMC:PMC3531444]
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Filtered by: None
Target
MAP1LC3A / LC3A (156)
Reactivity
Human (156)
Mouse (80)
Rat (56)
Bat (4)
Bovine (9)
Chicken (2)
Chimpanzee (6)
Dog (4)
Fish (1)
Gibbon (3)
Guinea pig (9)
Horse (8)
Monkey (7)
Opossum (3)
Pig (10)
Primate (6)
Pufferfish (1)
Xenopus (1)
Zebrafish (7)
Application
IHC (65)
IHC-P (23)
WB (134)
Flo (9)
DB (16)
ELISA (88)
ICC (25)
IF (20)
IP (8)
Peptide-ELISA (2)
Host
rabbit (132)
mouse (23)
sheep (1)
Isotype
Ig (1)
IgG (86)
IgG1 (2)
IgG1,k (9)
IgG2a (1)
IgG2a,k (7)
Clonality
monoclonal mc (23)
polyclonal pc (133)
Clone
10H6 (1)
166AT1234 (7)
2D5 (1)
4C5 (1)
5G10 (1)
Format
AP Conjugated (12)
APC (1)
APC Conjugated (13)
Azide-free (3)
Biotin Conjugated (17)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
DY488 Conjugated (3)
DY550 Conjugated (3)
DY650 Conjugated (3)
FITC Conjugated (16)
HRP Conjugated (16)
PE Conjugated (13)
Unconjugated (58)
Epitope
pSer12 (16)
N-Terminus (9)
aa89-120 (8)
aa91-117 (8)
Thr6 (7)
aa74-106 (7)
Thr12 (5)
aa96-125 (5)
Internal (4)
aa1-120 (4)
aa17-66 (4)
aa1-50 (3)
aa1-103 (1)
aa1-30 (1)
aa100-141 (1)
aa18-51 (1)
aa2-121 (1)
aa2-15 (1)
aa91-123 (1)
Publications
No (152)
Yes (4)
Showing 1-25 of 156 results

MAP1LC3A / LC3A Antibody (clone 5G10) IHC-plus™ LS-B14650
Mouse Monoclonal [clone 5G10] to Human MAP1LC3A / LC3A
Mouse, Rat, Human
IHC IHC-P WB
Unconjugated
50µl 1mg/ml  $425.00
Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE)
Western Blot (WB) analysis of 1) HeLa Cell Lysate, 2) 3T3 Cell Lysate, 3) Rat Brain Tissue Lysate using LC3A Mouse Monoclonal Antibody diluted at 1:1000.

MAP1LC3A / LC3A Antibody LS-C165694
Publications (1)
Publications (1)
Mouse Monoclonal (IgG1,k) to Human MAP1LC3A / LC3A
Mouse, Rat, Human
IF IHC WB
Unconjugated
400µl  $325.00
10X( lower panel) and 20X (upper panel) immunohistochemistry images from muscle tissue of a diseased mouse off Dox after 5 weeks on regular food. Several fibers that have autophagic vesicles throughout are visible. Data courtesy of Dr. Christy Caudill, Cincinnati Children's Hospital Medical Center.
Immunofluorescence of U251 cells, using LC3 Antibody (APG8). U251 cells(right) were treated with Chloroquine (50 mu M,16h). The antibody was diluted at 1:25 dilution. Dylight Fluor 488-conjugated goat anti-mouse lgG at 1:400 dilution was used as the secondary antibody (green). DAPI was used to stain the cell nuclear (blue).

MAP1LC3A / LC3A Antibody (aa1-30) LS-C165699
Publications (1)
Publications (1)
Rabbit Polyclonal to Human MAP1LC3A / LC3A
Mouse, Rat, Human
IF IHC IHC-P WB
Unconjugated
400µl  $325.00
Formalin-fixed and paraffin-embedded human brain tissue reacted with Autophagy LC3 Antibody (APG8a) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Fluorescent image of U251 cells stained LC3 (APG8A) antibody. U251 cells were treated with Chloroquine (50 mu M,16h), then fixed with 4% PFA (20 min), permeabilized with Triton X-100 (0.2%, 30 min). Cells were then incubated LC3 (APG8A) primary antibody (1:200, 2 h at room temperature). For secondary antibody, Alexa Fluor 488 conjugated donkey anti-rabbit antibody (green) was used (1:1000, 1h). Nuclei were counterstained with Hoechst 33342 (blue) (10 ug/ml, 5 min). LC3 immunoreactivity is localized to autophagic vacuoles in the cytoplasm of U251 cells.

MAP1LC3A / LC3A Antibody (aa89-120) LS-C159363
Publications (1)
Publications (1)
Rabbit Polyclonal to Human MAP1LC3A / LC3A
Mouse, Human
ICC IF IHC IHC-P WB
Unconjugated
400µl  $325.00
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Fluorescent image of U251 cells stained with cleaved LC3A antibody. U251 cells were fixed with 4% PFA (20 min), permeabilized with Triton X-100 (0.2%, 30 min). Cells were then incubated with cleaved LC3A primary antibody (1:100, 2 h at room temperature). For secondary antibody, Alexa Fluor 488 conjugated donkey anti-rabbit antibody (green) was used (1:1000, 1h). Nuclei were counterstained with Hoechst 33342 (blue) (10 ug/ml, 5 min). LC3 immunoreactivity is localized to autophagic vacuoles in the cytoplasm of U251 cells.

MAP1LC3A / LC3A Antibody (phospho-Ser12) LS-C158634
Publications (1)
Publications (1)
Rabbit Polyclonal to Human MAP1LC3A / LC3A
Human
DB WB
Unconjugated
400µl  $325.00
Immunoblots of phosphorylated LC3 (phospho-LC3) in CHO cell culture. LC3 and LC3 S12A mutant vectors were transfected into CHO cells. The cell lysates were separated with SDS-PAGE and blotted with anti-phospho-LC3 S12 antibody. LC3 = microtubule-associated protein light chain-3; S12A = replacement of the amino acid position 12 serine of LC3 with alanine. WT = wild type LC3-transfected cell lysates; S12A = LC3 S12A mutant-transfected cell lysates; Empty vector = vector with no LC3 gene. Molecular size: LC3-I = 16kDa, and LC3-II = 14 kDa
Immunoblots of SH-SY5Y cells treated with rapamycin for 1 h was probed. The data shows that treatment with rapamycin showed no significant change in level of LC3.

MAP1LC3A / LC3A Antibody LS-C497881
Rabbit Monoclonal to Human MAP1LC3A / LC3A
Mouse, Rat, Human
Flo IF IHC IP WB
Unconjugated
50µl  $295.00; 100µl  $385.00; 200µl  $560.00
Immunohistochemistry of paraffin-embedded mouse brain using MAP1LC3A antibodyat dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human liver using MAP1LC3A antibodyat dilution of 1:100 (40x lens).

MAP1LC3A / LC3A Antibody (aa74-106) LS-C322815
Rabbit Polyclonal (IgG) to Human MAP1LC3A / LC3A
Mouse, Human
ELISA Flo IHC WB
Unconjugated
200µl  $590.00

MAP1LC3A / LC3A Antibody (aa74-106, FITC) LS-C262516
Rabbit Polyclonal (IgG) to Human MAP1LC3A / LC3A
Mouse, Human
ELISA Flo IHC WB
FITC Conjugated
200µl  $740.00

MAP1LC3A / LC3A Antibody (aa74-106, PE) LS-C262523
Rabbit Polyclonal (IgG) to Human MAP1LC3A / LC3A
Mouse, Human
ELISA Flo IHC WB
PE Conjugated
200µl  $740.00

MAP1LC3A / LC3A Antibody (aa1-50) IHC-plus™ LS-B7938
Rabbit Polyclonal (IgG) to Human MAP1LC3A / LC3A
Zebrafish, Mouse, Bovine, Rat, Opossum, Human
IHC IHC-P WB
Unconjugated
50µg 0.5mg/ml  $425.00
Anti-LC3 antibody IHC of human brain, cortex neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml.
Western blot of LC3A in human brain lysate in the 1) absence and 2) presence of immunizing peptide, and in 3) mouse brain lysate, and 4) rat brain lysate using MAP1LC3A / LC3A Antibody at 1.0 ug/ml, 1.0 ug/ml, 0.1 ug/ml and 0.1 ug/ml, respectively. Goat anti-rabbit Ig HRP secondary antibody, and PicoTect ECL substrate solution, were used for this test.

MAP1LC3A / LC3A Antibody IHC-plus™ LS-B10152
Rabbit Polyclonal (IgG) to Human MAP1LC3A / LC3A
Human
ELISA IF IHC IHC-P WB
Unconjugated
0.05mg 1mg/ml  $425.00
Anti-MAP1LC3A / LC3A antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Anti-MAP1LC3A / LC3A antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

MAP1LC3A / LC3A Antibody (aa1-50) LS-C47386
Rabbit Polyclonal (IgG) to Human MAP1LC3A / LC3A
Xenopus, Chicken, Pufferfish, Rat, Opossum, Bovine, Mouse, Human, Monkey
IHC IHC-P WB
Unconjugated
100µg 0.5mg/ml  $335.00
IHC of normal human brain using antibody (APG8) at 5 ug/ml.
IHC of normal human brain using control (rabbit Ig) at 5 ug/ml.

MAP1LC3A / LC3A Antibody LS-C165695
Rabbit Polyclonal to Human MAP1LC3A / LC3A
Human
IF WB
Unconjugated
400µl  $325.00
Fluorescent image of U251 cells stained LC3 (APG8A) antibody.U251 cells were treated with Chloroquine (50 mu M,16h), then fixed with 4% PFA (20 min), permeabilized with Triton X-100 (0.2%, 30 min). Cells were then incubated LC3 (APG8A) primary antibody (1:200, 2 h at room temperature). For secondary antibody, Alexa Fluor 488 conjugated donkey anti-rabbit antibody (green) was used (1:1000, 1h). Nuclei were counterstained with Hoechst 33342 (blue) (10 ug/ml, 5 min). LC3 immunoreactivity is localized to autophagic vacuoles in the cytoplasm of U251 cells.
Western blot of LC3 (APG8a) (arrow) using purified antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the LC3 (APG8a) gene (Lane 2) (Origene Technologies).

MAP1LC3A / LC3A Antibody (clone 166AT1234) LS-C329173
Mouse Monoclonal [clone 166AT1234] (IgG1,k) to Human MAP1LC3A / LC3A
Mouse, Rat, Human
ICC IF IHC WB
Unconjugated
200µl  $590.00

MAP1LC3A / LC3A Antibody (clone 166AT1234, Biotin) LS-C221297
Mouse Monoclonal [clone 166AT1234] (IgG1,k) to Human MAP1LC3A / LC3A
Mouse, Rat, Human
ELISA ICC IF IHC WB
Biotin Conjugated
200µl  $740.00

MAP1LC3A / LC3A Antibody (clone 166AT1234, FITC) LS-C221299
Mouse Monoclonal [clone 166AT1234] (IgG1,k) to Human MAP1LC3A / LC3A
Mouse, Rat, Human
ELISA ICC IF IHC WB
FITC Conjugated
200µl  $740.00

MAP1LC3A / LC3A Antibody (clone 166AT1234, AP) LS-C221296
Mouse Monoclonal [clone 166AT1234] (IgG1,k) to Human MAP1LC3A / LC3A
Mouse, Rat, Human
ELISA ICC IF IHC WB
AP Conjugated
200µl  $740.00

MAP1LC3A / LC3A Antibody (clone 166AT1234, APC) LS-C221295
Mouse Monoclonal [clone 166AT1234] (IgG1,k) to Human MAP1LC3A / LC3A
Mouse, Rat, Human
ELISA ICC IF IHC WB
APC Conjugated
200µl  $740.00

MAP1LC3A / LC3A Antibody (clone 166AT1234, Azide-free, HRP) LS-C221298
Mouse Monoclonal [clone 166AT1234] (IgG1,k) to Human MAP1LC3A / LC3A
Mouse, Rat, Human
ELISA ICC IF IHC WB
HRP Conjugated, Azide-free
200µl  $740.00

MAP1LC3A / LC3A Antibody (clone 166AT1234, PE) LS-C221304
Mouse Monoclonal [clone 166AT1234] (IgG1,k) to Human MAP1LC3A / LC3A
Mouse, Rat, Human
ELISA ICC IF IHC WB
PE Conjugated
200µl  $740.00

MAP1LC3A / LC3A Antibody LS-C662547
Rabbit Polyclonal to Human MAP1LC3A / LC3A
Human
ELISA IHC IHC-P WB
Unconjugated
100µg  $325.00
Immunohistochemistry - Anti-MAP1LC3A Picoband antibody
Immunohistochemistry - Anti-MAP1LC3A Picoband antibody

MAP1LC3A / LC3A Antibody LS-C754977
Rabbit Polyclonal (IgG) to Human MAP1LC3A / LC3A
Human
ELISA Flo IF WB
Unconjugated
100µg  $335.00

MAP1LC3A / LC3A Antibody (N-Terminus) LS-C142708
Rabbit Polyclonal to Human MAP1LC3A / LC3A
Mouse, Rat, Human
Flo IHC IHC-P WB
Unconjugated
100µl  $335.00
LC3 Antibody - LC3 Antibody - IHC of LC3 in mouse liver.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
LC3 Antibody - Western Blot on human brain lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

MAP1LC3A / LC3A Antibody LS-C181882
Rabbit Polyclonal to Human MAP1LC3A / LC3A
Mouse, Bovine, Rat, Pig, Primate, Human
ICC IHC IHC-P WB
Unconjugated
100µl 1.09mg/ml  $335.00
Immunohistochemistry: LC3I Antibody - IHC of LC3I in mouse testis using DAB with hematoxylin counterstain.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Immunocytochemistry/Immunofluorescence: LC3I Antibody - LC3I antibody was tested in Neuro2a cells with FITC (green). Nuclei were counterstained with DAPI (blue).  This image was taken for the unconjugated form of this product. Other forms have not been tested.

MAP1LC3A / LC3A Antibody (aa17-66) LS-C170295
Rabbit Polyclonal to Rat MAP1LC3A / LC3A
Mouse, Guinea pig, Rat, Horse, Human
WB
Unconjugated
100µl 0.5mg/ml  $365.00
 This image was taken for the unconjugated form of this product. Other forms have not been tested.
Showing 1-25 of 156 results

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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