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Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed (By similarity). May play a role in colon tumorigenesis.
Gene Name: | methionyl aminopeptidase type 1D (mitochondrial) |
Synonyms: | METAP1D, MAP1D, Metap1l |
Target Sequences: | NM_199227 NP_954697.1 Q6UB28 |
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