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MANF / ARMET
mesencephalic astrocyte-derived neurotrophic factor
MANF / ARMET is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related.
| Gene Name: | mesencephalic astrocyte-derived neurotrophic factor |
| Synonyms: | MANF, ARP, ARMET, Arginine-rich protein, Protein ARMET |
| Target Sequences: | NM_006010 NP_006001.4 P55145 |
Publications (5)
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