MAGOH

mago-nashi homolog, proliferation-associated (Drosophila)

Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator WIBG/PYM leading to EJC disassembly in the cytoplasm and translation enhancement of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the function is different from the established EJC assembly.

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Proteins (8)

Type

Over-Expression Lysate (2)

Recombinant (6)

Target

MAGOH (8)

Publications

No (8)

Tag

GST (1)

GST, N-terminus (2)

His (2)

His, N-Terminal (1)

Myc-DDK (Flag) (2)

Species

Human (7)

Source

293T Cells (1)

E. coli (4)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (4)

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Human MAGOH Protein (Recombinant GST, N-terminus) (aa1-110) - LS-G59176

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human MAGOH Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G87603

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

17 kDa

Price:

20 µg/$150

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MAGOH Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G118034

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

17 kDa

Price:

100 µg/$494

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Human MAGOH Protein (Recombinant His, N-Terminal) - LS-G144754

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

17 kDa

Price:

50 µg/$419

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Human MAGOH Protein (Recombinant GST) (Full Length) - LS-G29261

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

43.6 kDa

Price:

10 µg/$479; 25 µg/$670

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Human MAGOH Protein (Recombinant GST, N-terminus) (aa1-146) - LS-G56389

Source:

E. coli

Tag:

GST, N-terminus

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human MAGOH Protein (Recombinant His) (Met1-Ile146) - LS-G97670

Source:

E. coli

Tag:

His

Molecular Weight:

18 kDa

Price:

100 µg/$721

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Human MAGOH Protein (Recombinant His) - LS-G758

Source:

E. coli

Tag:

His

Price:

100 µg/$342; 500 µg/$641; 20 µg/$254

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