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MAGED1 / NRAGE

melanoma antigen family D, 1

Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as ARNTL/BMAL1 and NFIL3, induced, or NR1D1, repressed.

Gene Name: melanoma antigen family D, 1
Synonyms: MAGED1, DLXIN-1, MAGE-D1 antigen, Melanoma antigen family D, 1, NRAGE, MAGE tumor antigen CCF, Melanoma-associated antigen D1
Target Sequences: NM_006986 NP_008917.3

Publications (1)

1
NRAGE promotes the malignant phenotype of hepatocellular carcinoma. Shimizu D, Kanda M, Sugimoto H, Sueoka S, Takami H, Ezaka K, Tanaka Y, Hashimoto R, Okamura Y, Iwata N, Tanaka C, Yamada S, Fujii T, Nakayama G, Koike M, Nomoto S, Fujiwara M, Kodera Y. Oncology letters. 2016 11:1847-1854. (WB; Human) [Full Text Article] [PubMed:26998088] [PMC:PMC4774420] Related Antibodies: LS-C100414.

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Proteins (10)
Over-Expression Lysate (6)
Recombinant (4)
MAGED1 / NRAGE (10)
No (10)
GST (2)
GST, N-terminus (1)
His (1)
Myc-DDK (Flag) (6)
Human (7)
293T Cells (3)
E. coli (1)
HEK 293 Cells (3)
Wheat Germ Extract (3)
Purified (3)
MAGED1 / NRAGE Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
86 kDa
100 µg/$494
MAGED1 / NRAGE Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
91.8 kDa
100 µg/$494
MAGED1 / NRAGE Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
86 kDa
100 µg/$494
MAGED1 / NRAGE Protein
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E. coli
His
10 µg/$361; 50 µg/$739
MAGED1 / NRAGE Protein - 12.5% SDS-PAGE of human MAGED1 stained with Coomassie Blue
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Wheat Germ Extract
GST
111.1 kDa
2 µg/$439
MAGED1 / NRAGE Protein - 12.5% SDS-PAGE of human MAGED1 stained with Coomassie Blue
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Wheat Germ Extract
GST
112.6 kDa
2 µg/$439
MAGED1 / NRAGE Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
MAGED1 / NRAGE Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
91.8 kDa
20 µg/$150
MAGED1 / NRAGE Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
86 kDa
20 µg/$150
MAGED1 / NRAGE Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
86 kDa
20 µg/$150
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).