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MAGE10 / MAGEA10
melanoma antigen family A, 10
MAGE10 / MAGEA10 is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream melanoma antigen family A, 5 (MAGEA5) gene.
| Gene Name: | melanoma antigen family A, 10 |
| Synonyms: | MAGEA10, Cancer/testis antigen 1.10, CT1.10, MAGE10, MAGE-10 antigen, Melanoma antigen family A, 10, Melanoma-associated antigen 10 |
| Target Sequences: | NM_001011543 NP_001011543.2 P43363 |
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