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MAEL
maelstrom spermatogenic transposon silencer
Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage.
| Gene Name: | maelstrom spermatogenic transposon silencer |
| Synonyms: | MAEL, Cancer/testis antigen 128, Maelstrom homolog (Drosophila), Protein maelstrom homolog, SPATA35, CT128, RP11-102C16.1 |
| Target Sequences: | NM_032858 CAB61396.1 Q96JY0 |
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