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LYRM1 belongs to the mitochondrial leucine/tyrosine/arginine motif family of proteins. Proteins of this family are short polypeptides that contain a leucine/tyrosine/arginine motif near the N-terminus. This gene is widely expressed with high levels in omental adipose tissue of obese individuals. In adipose tissue, the protein is localized to the nucleus where it promotes preadipocyte proliferation and lowers the rate of apoptosis to regulate adipose tissue homeostasis. Overexpression of this gene in adipocytes causes abnormal mitochondrial morphology and mitochondrial dysfunction. Alternative splicing results in multiple transcript variants.
Gene Name: | LYR motif containing 1 |
Synonyms: | LYRM1, A211C6.1, LYR motif-containing protein 1, LYR motif containing 1 |
Target Sequences: | NM_020424 NP_065157.1 O43325 |
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