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LRWD1
leucine-rich repeats and WD repeat domain containing 1
Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3 in a cooperative manner with DNA methylation. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability.
| Gene Name: | leucine-rich repeats and WD repeat domain containing 1 |
| Synonyms: | LRWD1, Centromere protein 33, ORC-associated protein, ORCA, CENP-33 |
| Target Sequences: | NM_152892 NP_690852.1 Q9UFC0 |
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