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LRRC16 / CARMIL

Leucine Rich Repeat Containing 16A

Binds CAPZA2 with high affinity and significantly decreases CAPZA2 affinity for actin barbed ends. Increases the rate of elongation from seeds in the presence of CAPZA2, however, seems unable to nucleate filaments. Rapidly uncaps barbed ends capped by CAPZA2 and enhances barbed-end actin polymerization By similarity. May control actin dynamics in lamellipodia. Required for cell migration.

Gene Name:	Leucine Rich Repeat Containing 16A
Synonyms:	LRRC16A, CARMIL, CARMIL1a, CARMIL homolog, DJ501N12.5, LRRC16, CARMIL1, DJ501N12.1
Target Sequences:	NM_017640 NP_060110.4

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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