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LRP6

low density lipoprotein receptor-related protein 6

Low Density Lipoprotein Receptor-Related Protein 6 (LRP6) is a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. LRP6 functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade LRP6 plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. LRP6 undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.

Gene Name: low density lipoprotein receptor-related protein 6
Synonyms: LRP6, ADCAD2, LRP-6
Target Sequences: NM_002336 NP_002327.2 O75581

Publications (2)

1
LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy. Liu CC, Prior J, Piwnica-Worms D, Bu G. Proceedings of the National Academy of Sciences of the United States of America. 2010 107:5136-41. [PubMed:20194742] [PMC:PMC2841938] Related Antibodies: LS-C100405.
2
Systems Genetics Analysis of a Recombinant Inbred Mouse Cell Culture Panel Reveals Wnt Pathway Member Lrp6 as a Regulator of Adult Hippocampal Precursor Cell Proliferation. Kannan S, Nicola Z, Overall RW, Ichwan M, Ramírez-Rodríguez G, N Grzyb A, Patone G, Saar K, Hübner N, Kempermann G. Stem cells (Dayton, Ohio). 2016 March;34:674-84. (Human) [Full Text Article] [PubMed:26840599]

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LRP6 ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
LRP6 ELISA Kit
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Sandwich
96-Well Strip Plate
Porcine
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
LRP6 ELISA Kit
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Sandwich
96-Well Strip Plate
Sheep
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$760
LRP6 ELISA Kit
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Sandwich
96-Well Strip Plate
Rabbit
125 - 8000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
LRP6 ELISA Kit
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Sandwich
96-Well Strip Plate
Chicken
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
LRP6 ELISA Kit
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Custom
96-Well Strip Plate
Human
Colorimetric - 450nm (TMB)
1 Plate/$783
LRP6 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
LRP6 ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Human
62.5 - 4000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
LRP6 ELISA Kit
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Sandwich
96-Well Microplate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
LRP6 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
1 - 25 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
LRP6 ELISA Kit
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Competitive EIA
96-Well Strip Plate
Rat
1 - 25 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
LRP6 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
LRP6 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
LRP6 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Tissue Homogenates
1 Plate/$834
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).