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LPXN / Leupaxin

Leupaxin

Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling.

Gene Name: Leupaxin
Synonyms: LPXN, LDLP, Leupaxin, LDPL
Target Sequences: NM_004811 NP_004802.1 O60711

Publications (1)

1
Protein tyrosine kinase 2b inhibition reverts niche-associated resistance to tyrosine kinase inhibitors in AML. Catana Allert, Alexander Waclawiczek , Sarah Miriam Naomi Zimmermann , Stefanie Göllner, Daniel Heid, Maike Janssen, Simon Renders, Christian Rohde, Marcus Bauer, Margarita Bruckmann, Rafael Zinz, Cornelius Pauli, Birgit Besenbeck, Claudia Wickenhauser, Andreas Trumpp, Jeroen Krijgsveld, Carsten Müller-Tidow, Maximilian Felix Blank. Leukemia. 2022 October;36:2418-2429. [Full Text Article] [PubMed:36056084] [PMC:PMC9522596] Related Antibodies: LS-C313296.

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Proteins (7)
Over-Expression Lysate (4)
Recombinant (3)
LPXN / Leupaxin (7)
No (7)
GST (1)
His, N-Terminal (1)
His-T7 (1)
Myc-DDK (Flag) (4)
Human (4)
Mouse (1)
293T Cells (2)
E. coli (2)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Purified (2)
LPXN / Leupaxin Protein - 12.5% SDS-PAGE of human LPXN stained with Coomassie Blue
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Wheat Germ Extract
GST
68.2 kDa
10 µg/$479; 25 µg/$670
LPXN / Leupaxin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
43.6 kDa
100 µg/$494
LPXN / Leupaxin Protein - Recombinant Leupaxin (LPXN) by SDS-PAGE
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E. coli
His, N-Terminal
26.3kDa
10 µg/$267; 50 µg/$352; 200 µg/$702; 100 µg/$562; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900
LPXN / Leupaxin Protein - Recombinant Leupaxin By SDS-PAGE
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E. coli
His-T7
26.8 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
LPXN / Leupaxin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
43.6 kDa
20 µg/$150
LPXN / Leupaxin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
43.2 kDa
20 µg/$150
LPXN / Leupaxin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
43.2 kDa
100 µg/$494
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).