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LPAR2 / EDG4

lysophosphatidic acid receptor 2

Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation.

Gene Name: lysophosphatidic acid receptor 2
Family/Subfamily: GPCR , Lysophospholipid/Lysosphingolipid
Synonyms: LPAR2, EDG4, LPA-2, LPA receptor 2, LPA receptor EDG4, LPA2, EDG-4
Target Sequences: NM_004720 NP_004711.2 Q9HBW0

Publications (2)

1
Nm23-H1 suppresses tumor cell motility by down-regulating the lysophosphatidic acid receptor EDG2. Horak CE, Lee JH, Elkahloun AG, Boissan M, Dumont S, Maga TK, Arnaud-Dabernat S, Palmieri D, Stetler-Stevenson WG, Lacombe ML, Meltzer PS, Steeg PS. Cancer research. 2007 67:7238-46. (WB; Human) [PubMed:17671192] Related Antibodies: LS-C100388.
2
Elevated plasma levels of lysophosphatidic acid and aberrant expression of lysophosphatidic acid receptors in adenomyosis. Yang B, Wang L, Wan X, Li Y, Yu X, Qin Y, Luo Y, Wang F, Huang O. BMC women's health. 2017 November;17:118. (Human) [Full Text Article] [PubMed:29178922] [PMC:PMC5702234] Related Antibodies: LS-B512.

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Proteins (4)
Over-Expression Lysate (2)
Recombinant (2)
LPAR2 / EDG4 (4)
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GST (2)
Myc-DDK (Flag) (2)
Human (3)
293T Cells (1)
HEK 293 Cells (1)
Wheat Germ Extract (2)
Purified (2)
LPAR2 / EDG4 Protein - 12.5% SDS-PAGE of human EDG4 stained with Coomassie Blue
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Wheat Germ Extract
GST
64.35 kDa
2 µg/$439
LPAR2 / EDG4 Protein - 12.5% SDS-PAGE of human EDG4 stained with Coomassie Blue
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Wheat Germ Extract
GST
65.5 kDa
2 µg/$439
LPAR2 / EDG4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
38.9 kDa
20 µg/$150
LPAR2 / EDG4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
38.9 kDa
100 µg/$494
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).