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LOXL2

lysyl oxidase-like 2

Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Involved in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of E-cadherin, probably by mediating deamination of histone H3. Also involved in E-cadherin repression following hypoxia, a hallmark of epithelial to mesenchymal transition believed to amplify tumor aggressiveness, suggesting that it may play a role in tumor progression. Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation.

Gene Name: lysyl oxidase-like 2
Synonyms: LOXL2, Lysyl oxidase-like protein 2, Lysyl oxidase related 2, Lysyl oxidase-like 2, WS9-14, LOR2, Lysyl oxidase homolog 2
Target Sequences: NM_002318 NP_002309.1 Q9Y4K0

Publications (1)

1
B lymphocytes directly contribute to tissue fibrosis in patients with IgG4-related disease. Emanuel Della-Torre, Elena Rigamonti, Cory Perugino, Simona Baghai-Sain, Na Sun, Naoki Kaneko, Takashi Maehara, Lucrezia Rovati, Maurilio Ponzoni, Raffaella Milani, Marco Lanzillotta, Vinay Mahajan, Hamid Mattoo, Ivan Molineris, Vikram Deshpande, John H Stone, Massimo Falconi, Angelo A Manfredi, Shiv Pillai. The Journal of allergy and clinical immunology. 2019 Mar;145:968-981e14. [Full Text Article] [PubMed:31319101] [PMC:PMC6960365] Related Antibodies: LS-A9350.

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Proteins (11)
Over-Expression Lysate (2)
Recombinant (9)
LOXL2 (11)
SDS-PAGE (1)
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GST, N-terminus (1)
His (6)
His, N-Terminal (1)
His,C-terminus (1)
Myc-DDK (Flag) (2)
Human (4)
Mouse (4)
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293T Cells (1)
E. coli (6)
HEK 293 Cells (2)
Wheat Germ Extract (1)
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LOXL2 Protein
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E. coli
His
13.3 kDa
10 µg/$283; 50 µg/$452; 100 µg/$725; 200 µg/$905; 1 mg/$2,020; 500 µg/$1,558; 5 mg/$3,165; 2 mg/$2,209
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HEK 293 Cells
His,C-terminus
SDS-PAGE
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant mouse Loxl2 consists 762 amino acids and predicts a molecular mass of 85.9 kDa.
100 µg/$480
LOXL2 Protein - Recombinant Lysyl Oxidase Like Protein 2 By SDS-PAGE
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E. coli
His, N-Terminal
12.8 kDa
10 µg/$291; 50 µg/$502; 200 µg/$1,002; 1 mg/$2,144; 5 mg/$3,501; 2 mg/$2,334
LOXL2 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
LOXL2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
86.71 kDa
20 µg/$150
Select
E. coli
His
88.48 kD
1 mg/$1,679; 100 µg/$500; 20 µg/$364
LOXL2 Protein
Select
Yeast
His
86.43 kD
100 µg/$499; 20 µg/$364; 1 mg/$1,683
LOXL2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
86.71 kDa
100 µg/$494
Select
E. coli
His
13.9 kDa
10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231
LOXL2 Protein - Recombinant Lysyl Oxidase Like Protein 2 By SDS-PAGE
Select
E. coli
His
25.6 kDa
10 µg/$291; 50 µg/$502; 100 µg/$802; 200 µg/$1,002; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334
Select
E. coli
His
25.8 kDa
10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).