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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Infectious Disease
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LOX / Lysyl Oxidase

lysyl oxidase

Lysyl Oxidase / LOX is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression. Defects in this gene are a cause of autosomal recessive cutis laxa type I (CL type I). Two transcript variants encoding different isoforms have been found for this gene.

Gene Name: lysyl oxidase
Synonyms: LOX, Lysyl oxidase, Protein-lysine 6-oxidase
Target Sequences: NM_002317 NP_002308.2 P28300

Publications (14)

1
Lysyl oxidase inhibits ras-mediated transformation by preventing activation of NF-kappa B. Jeay S, Pianetti S, Kagan HM, Sonenshein GE. Molecular and cellular biology. 2003 23:2251-63. [PubMed:12640111] [PMC:PMC150722]
2
The propeptide domain of lysyl oxidase induces phenotypic reversion of ras-transformed cells. Palamakumbura AH, Jeay S, Guo Y, Pischon N, Sommer P, Sonenshein GE, Trackman PC. The Journal of biological chemistry. 2004 279:40593-600. [PubMed:15277520]
3
Tumor suppressive effect of lysyl oxidase proenzyme. Contente S, Yeh TJ, Friedman RM. Biochimica et biophysica acta. 2009 1793:1272-8. [PubMed:19410608]
4
Fibulin-4 conducts proper elastogenesis via interaction with cross-linking enzyme lysyl oxidase. Horiguchi M, Inoue T, Ohbayashi T, Hirai M, Noda K, Marmorstein LY, Yabe D, Takagi K, Akama TO, Kita T, Kimura T, Nakamura T. Proceedings of the National Academy of Sciences of the United States of America. 2009 106:19029-34. [PubMed:19855011] [PMC:PMC2776456]
5
Induction of cardiac fibroblast lysyl oxidase by TGF-1 requires PI3K/Akt, Smad3, and MAPK signaling. Voloshenyuk TG, Landesman ES, Khoutorova E, Hart AD, Gardner JD. Cytokine. 2011 55:90-7. (WB; Rat) [PubMed:21498085]
6
The Ras signaling inhibitor LOX-PP interacts with Hsp70 and c-Raf to reduce Erk activation and transformed phenotype of breast cancer cells. Sato S, Trackman PC, Mki JM, Myllyharju J, Kirsch KH, Sonenshein GE. Molecular and cellular biology. 2011 31:2683-95. [PubMed:21536655] [PMC:PMC3133379]
7
Transforming growth factor-beta induces extracellular matrix protein cross-linking lysyl oxidase (LOX) genes in human trabecular meshwork cells. Sethi A, Mao W, Wordinger RJ, Clark AF. Investigative ophthalmology & visual science. 2011 52:5240-50. [PubMed:21546528] [PMC:PMC3176072]
8
The lysyl oxidase propeptide interacts with the receptor-type protein tyrosine phosphatase kappa and inhibits -catenin transcriptional activity in lung cancer cells. Snchez-Morgan N, Kirsch KH, Trackman PC, Sonenshein GE. Molecular and cellular biology. 2011 31:3286-97. [PubMed:21690299] [PMC:PMC3147807]
9
Copper deficiency induced emphysema is associated with focal adhesion kinase inactivation. Mizuno S, Yasuo M, Bogaard HJ, Kraskauskas D, Alhussaini A, Gomez-Arroyo J, Farkas D, Farkas L, Voelkel NF. PloS one. 2012 7:e30678. [PubMed:22276220] [PMC:PMC3262830]
10
Recombinant lysyl oxidase propeptide protein inhibits growth and promotes apoptosis of pre-existing murine breast cancer xenografts. Bais MV, Nugent MA, Stephens DN, Sume SS, Kirsch KH, Sonenshein GE, Trackman PC. PloS one. 2012 7:e31188. [PubMed:22363577] [PMC:PMC3280126]
11
A new model of experimental fibrosis in hindlimb skeletal muscle of adult mdx mouse mimicking muscular dystrophy. Desguerre I, Arnold L, Vignaud A, Cuvellier S, Yacoub-Youssef H, Gherardi RK, Chelly J, Chretien F, Mounier R, Ferry A, Chazaud B. Muscle & nerve. 2012 45:803-14. (IHC; Mouse) [PubMed:22581532]
12
The role of lysyl oxidase family members in the stabilization of abdominal aortic aneurysms. Remus EW, O'Donnell RE, Rafferty K, Weiss D, Joseph G, Csiszar K, Fong SF, Taylor WR. American journal of physiology. Heart and circulatory physiology. 2012 303:H1067-75. (WB; Mouse) [PubMed:22904155] [PMC:PMC3469640]
13
Changes in lysyl oxidase (LOX) distribution and its decreased activity in keratoconus corneas. Dudakova L, Liskova P, Trojek T, Palos M, Kalasova S, Jirsova K. Experimental eye research. 2012 104:74-81. (ICC, IHC-Fr; Human) [PubMed:23041260]
14
Insight On Colorectal Carcinoma Infiltration by Studying Perilesional Extracellular Matrix. Nebuloni M, Albarello L, Andolfo A, Magagnotti C, Genovese L, Locatelli I, Tonon G, Longhi E, Zerbi P, Allevi R, Podestà A, Puricelli L, Milani P, Soldarini A, Salonia A, Alfano M. Scientific reports. 2016 6:22522. (WB; Human) [Full Text Article] [PubMed:26940881] [PMC:PMC4778019] Related Antibodies: LS-C114933.
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LOX / Lysyl Oxidase Antibody - Anti-Lysyl Oxidase / LOX antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human LOX / Lysyl Oxidase
Rat, Human
Flo, ICC, IF, IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $425.00
LOX / Lysyl Oxidase Antibody - Anti-Lysyl Oxidase / LOX antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human LOX / Lysyl Oxidase
Rat, Human
Flo, ICC, IF, IHC, IHC-P, WB
Biotin Conjugated
100µl   $365.00
LOX / Lysyl Oxidase Antibody - Anti-Lysyl Oxidase / LOX antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human LOX / Lysyl Oxidase
Rat, Human
Flo, ICC, IF, IHC, IHC-P, WB
DY650 Conjugated
100µl   $365.00
LOX / Lysyl Oxidase Antibody - Anti-Lysyl Oxidase / LOX antibody IHC staining of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Rabbit Polyclonal to Rat LOX / Lysyl Oxidase
Mouse, Rat, Primate, Human
IHC, IHC-P, WB
Unconjugated
100µl   $425.00
LOX / Lysyl Oxidase Antibody - Anti-Lysyl Oxidase / LOX antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Select
Mouse Monoclonal [clone 9A11] (IgG1) to Human LOX / Lysyl Oxidase
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
50µl   $425.00
LOX / Lysyl Oxidase Antibody - Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal (IgG) to Rat LOX / Lysyl Oxidase
Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µg   3mg/ml   $425.00
LOX / Lysyl Oxidase Antibody - IHC of paraffin-embedded Human thyroid tissue using anti-LOX mouse monoclonal antibody.
Select
Mouse Monoclonal [clone OTI9G2] (IgG1) to Human LOX / Lysyl Oxidase
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $345.00
LOX / Lysyl Oxidase Antibody - Western blot of LOX in A) human skin and B) mouse ear skin lysate using Polyclonal Antibody to Lysyl Oxidase (LOX) at 1:500. Goat anti-rabbit Ig HRP secondary antibody, and PicoTect ECL substrate solution, were used for this test.
Select
Rabbit Polyclonal to Human LOX / Lysyl Oxidase
Rabbit, Mouse, Bat, Human, Monkey
IHC, IHC-Fr, IP, WB
Unconjugated
100µl   $335.00
LOX / Lysyl Oxidase Antibody - LOX propeptide Antibody - IHC of LOPP in mouse intestine.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Mouse LOX / Lysyl Oxidase
Mouse, Rat, Pig, Primate, Human
IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $335.00
LOX / Lysyl Oxidase Antibody - Human placental villi, 40X. Staining of placental trophoblasts using antibody at 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human LOX / Lysyl Oxidase
Mouse, Bovine, Rat, Pig, Human
IHC, IHC-P, WB
Unconjugated
50µl   1mg/ml   $335.00
LOX / Lysyl Oxidase Antibody - Human placental villi, 40X. Staining of placental trophoblasts using antibody at 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human LOX / Lysyl Oxidase
Mouse, Bovine, Rat, Pig, Human
IHC, IHC-P, WB
Biotin Conjugated
50µl   0.85mg/ml   $365.00
LOX / Lysyl Oxidase Antibody - LOpep4 Antibody - Western blot on cytoplasmic (c) and nuclear (n) extracts of NIH 3T3, ras-transformed (RS 485), PMEF and TGM-1 mouse fibroblast cells.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human LOX / Lysyl Oxidase
Mouse, Rat, Human
IHC, WB
Unconjugated
100µl   1mg/ml   $335.00
LOX / Lysyl Oxidase Antibody - Western blot of recombinant Lysyl Oxidase / LOX.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human LOX / Lysyl Oxidase
Human
WB
Unconjugated
100µl   0.5mg/ml   $255.00; 200µl   0.5mg/ml   $305.00; 500µl   0.5mg/ml   $445.00; 1ml   0.5mg/ml   $530.00
LOX / Lysyl Oxidase Antibody - IHC of paraffin-embedded colon tissue using anti-LOX mouse monoclonal antibody. (Dilution 1:50).
Select
Mouse Monoclonal [clone OTI8G5] (IgG1) to Human LOX / Lysyl Oxidase
Human
IF, IHC, IHC-P, WB
Unconjugated
100µl   $345.00
Select
Rabbit Polyclonal (IgG) to Rat LOX / Lysyl Oxidase
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
100µl   $530.00
LOX / Lysyl Oxidase Antibody - IHC of paraffin-embedded colon tissue using anti- mouse monoclonal antibody. (Dilution 1:50).
Select
Mouse Monoclonal [clone OTI5C4] (IgG1) to Human LOX / Lysyl Oxidase
Dog, Rat, Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $345.00
LOX / Lysyl Oxidase Antibody - IHC of paraffin-embedded liver tissue using anti-LOX mouse monoclonal antibody. (Dilution 1:50).
Select
Mouse Monoclonal [clone OTI6B7] (IgG1) to Human LOX / Lysyl Oxidase
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $345.00
LOX / Lysyl Oxidase Antibody - IHC of paraffin-embedded liver tissue using anti-LOX mouse monoclonal antibody. (Dilution 1:50).
Select
Mouse Monoclonal [clone OTI6B7] (IgG1) to Human LOX / Lysyl Oxidase
Human
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100µg   $395.00
LOX / Lysyl Oxidase Antibody - IHC of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-LOX mouse monoclonal antibody.
Select
Mouse Monoclonal [clone OTI10D11] (IgG1) to Human LOX / Lysyl Oxidase
Human
IF, IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $345.00
Select
Mouse Monoclonal (IgG2b) to Human LOX / Lysyl Oxidase
Human
ELISA, WB
Biotin Conjugated
200µl   $740.00
LOX / Lysyl Oxidase Antibody - Immunohistochemical staining of paraffin-embedded Human Kidney tissue using anti-LOX mouse monoclonal antibody. (Dilution 1:50).
Select
Mouse Monoclonal [clone OTI4E3] (IgG1) to Human LOX / Lysyl Oxidase
Flo, IF, IHC, IHC-P, WB
Unconjugated
100µl   0.42mg/ml   $345.00
LOX / Lysyl Oxidase Antibody - Immunohistochemistry of paraffin-embedded Human lung cancer using LOX Polyclonal Antibody at dilution of 1:30.
Select
Rabbit Polyclonal (IgG) to Human LOX / Lysyl Oxidase
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20µl   0.3mg/ml   $205.00; 60µl   0.3mg/ml   $235.00; 120µl   0.3mg/ml   $295.00; 200µl   0.3mg/ml   $395.00
LOX / Lysyl Oxidase Antibody - Western blot of LOX Antibody in MDA-MB468 cell line lysates (35 ug/lane). LOX (arrow) was detected using the purified antibody.
Select
Rabbit Polyclonal to Human LOX / Lysyl Oxidase
Human
Flo, WB
Unconjugated
400µl   $325.00
LOX / Lysyl Oxidase Antibody - IHC of paraffin-embedded colon tissue using anti-LOX mouse monoclonal antibody. (Dilution 1:50).
Select
Mouse Monoclonal [clone OTI9G6] (IgG1) to Human LOX / Lysyl Oxidase
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $345.00
LOX / Lysyl Oxidase Antibody - Immunohistochemical staining of paraffin-embedded endometrium tissue using anti-LOX mouse monoclonal antibody. (Dilution 1:50).
Select
Mouse Monoclonal [clone OTI6B11] (IgG1) to Human LOX / Lysyl Oxidase
Flo, IF, IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $345.00
Viewing 1-25 of 104 products



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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).