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Immunohistochemistry Services

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LOX / Lysyl Oxidase

lysyl oxidase

Lysyl Oxidase / LOX is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression. Defects in this gene are a cause of autosomal recessive cutis laxa type I (CL type I). Two transcript variants encoding different isoforms have been found for this gene.

Gene Name: lysyl oxidase
Synonyms: LOX, Lysyl oxidase, Protein-lysine 6-oxidase
Target Sequences: NM_002317 NP_002308.2 P28300

Publications (14)

1
Lysyl oxidase inhibits ras-mediated transformation by preventing activation of NF-kappa B. Jeay S, Pianetti S, Kagan HM, Sonenshein GE. Molecular and cellular biology. 2003 23:2251-63. [PubMed:12640111] [PMC:PMC150722]
2
The propeptide domain of lysyl oxidase induces phenotypic reversion of ras-transformed cells. Palamakumbura AH, Jeay S, Guo Y, Pischon N, Sommer P, Sonenshein GE, Trackman PC. The Journal of biological chemistry. 2004 279:40593-600. [PubMed:15277520]
3
Tumor suppressive effect of lysyl oxidase proenzyme. Contente S, Yeh TJ, Friedman RM. Biochimica et biophysica acta. 2009 1793:1272-8. [PubMed:19410608]
4
Fibulin-4 conducts proper elastogenesis via interaction with cross-linking enzyme lysyl oxidase. Horiguchi M, Inoue T, Ohbayashi T, Hirai M, Noda K, Marmorstein LY, Yabe D, Takagi K, Akama TO, Kita T, Kimura T, Nakamura T. Proceedings of the National Academy of Sciences of the United States of America. 2009 106:19029-34. [PubMed:19855011] [PMC:PMC2776456]
5
Induction of cardiac fibroblast lysyl oxidase by TGF-1 requires PI3K/Akt, Smad3, and MAPK signaling. Voloshenyuk TG, Landesman ES, Khoutorova E, Hart AD, Gardner JD. Cytokine. 2011 55:90-7. (WB; Rat) [PubMed:21498085]
6
The Ras signaling inhibitor LOX-PP interacts with Hsp70 and c-Raf to reduce Erk activation and transformed phenotype of breast cancer cells. Sato S, Trackman PC, Mki JM, Myllyharju J, Kirsch KH, Sonenshein GE. Molecular and cellular biology. 2011 31:2683-95. [PubMed:21536655] [PMC:PMC3133379]
7
Transforming growth factor-beta induces extracellular matrix protein cross-linking lysyl oxidase (LOX) genes in human trabecular meshwork cells. Sethi A, Mao W, Wordinger RJ, Clark AF. Investigative ophthalmology & visual science. 2011 52:5240-50. [PubMed:21546528] [PMC:PMC3176072]
8
The lysyl oxidase propeptide interacts with the receptor-type protein tyrosine phosphatase kappa and inhibits -catenin transcriptional activity in lung cancer cells. Snchez-Morgan N, Kirsch KH, Trackman PC, Sonenshein GE. Molecular and cellular biology. 2011 31:3286-97. [PubMed:21690299] [PMC:PMC3147807]
9
Copper deficiency induced emphysema is associated with focal adhesion kinase inactivation. Mizuno S, Yasuo M, Bogaard HJ, Kraskauskas D, Alhussaini A, Gomez-Arroyo J, Farkas D, Farkas L, Voelkel NF. PloS one. 2012 7:e30678. [PubMed:22276220] [PMC:PMC3262830]
10
Recombinant lysyl oxidase propeptide protein inhibits growth and promotes apoptosis of pre-existing murine breast cancer xenografts. Bais MV, Nugent MA, Stephens DN, Sume SS, Kirsch KH, Sonenshein GE, Trackman PC. PloS one. 2012 7:e31188. [PubMed:22363577] [PMC:PMC3280126]
11
A new model of experimental fibrosis in hindlimb skeletal muscle of adult mdx mouse mimicking muscular dystrophy. Desguerre I, Arnold L, Vignaud A, Cuvellier S, Yacoub-Youssef H, Gherardi RK, Chelly J, Chretien F, Mounier R, Ferry A, Chazaud B. Muscle & nerve. 2012 45:803-14. (IHC; Mouse) [PubMed:22581532]
12
The role of lysyl oxidase family members in the stabilization of abdominal aortic aneurysms. Remus EW, O'Donnell RE, Rafferty K, Weiss D, Joseph G, Csiszar K, Fong SF, Taylor WR. American journal of physiology. Heart and circulatory physiology. 2012 303:H1067-75. (WB; Mouse) [PubMed:22904155] [PMC:PMC3469640]
13
Changes in lysyl oxidase (LOX) distribution and its decreased activity in keratoconus corneas. Dudakova L, Liskova P, Trojek T, Palos M, Kalasova S, Jirsova K. Experimental eye research. 2012 104:74-81. (ICC, IHC-Fr; Human) [PubMed:23041260]
14
Insight On Colorectal Carcinoma Infiltration by Studying Perilesional Extracellular Matrix. Nebuloni M, Albarello L, Andolfo A, Magagnotti C, Genovese L, Locatelli I, Tonon G, Longhi E, Zerbi P, Allevi R, Podestà A, Puricelli L, Milani P, Soldarini A, Salonia A, Alfano M. Scientific reports. 2016 6:22522. (WB; Human) [Full Text Article] [PubMed:26940881] [PMC:PMC4778019] Related Antibodies: LS-C114933.
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Target
LOX / Lysyl Oxidase (106)
Reactivity
Human (92)
Mouse (32)
Rat (34)
Bat (1)
Bovine (5)
Dog (2)
Monkey (1)
Pig (4)
Primate (2)
Rabbit (1)
Application
IHC (57)
IHC-Fr (1)
IHC-P (31)
WB (102)
Flo (24)
ELISA (32)
ICC (5)
IF (35)
IP (3)
Peptide-ELISA (1)
Host
rabbit (72)
mouse (33)
goat (1)
Isotype
IgG (25)
IgG1 (24)
IgG2b (8)
Clonality
monoclonal mc (33)
polyclonal pc (73)
Clone
624CT23.7.3 (6)
9A11 (2)
OTI10D11 (2)
OTI3C3 (2)
OTI4E3 (2)
OTI5C4 (2)
OTI6B11 (2)
OTI6B7 (2)
OTI7E6 (2)
OTI8G5 (2)
OTI9B5 (2)
OTI9G2 (2)
OTI9G6 (2)
Format
AP Conjugated (2)
APC (2)
APC Conjugated (4)
Azide-free (1)
Biotin Conjugated (11)
Carrier-free (12)
Cy3 Conjugated (2)
Cy7 Conjugated (2)
DY488 Conjugated (5)
DY550 Conjugated (5)
DY650 Conjugated (5)
FITC Conjugated (6)
HRP Conjugated (6)
PE Conjugated (4)
Unconjugated (54)
Epitope
aa234-260 (16)
aa22-168 (12)
aa207-411 (8)
aa213-417 (8)
Internal (5)
aa118-168 (5)
aa135-155 (5)
aa300-400 (5)
aa300-350 (4)
aa181-196 (1)
aa240-268 (1)
aa305-320 (1)
aa78-115 (1)
internal region (1)
Publications
No (105)
Yes (1)
Showing 1-25 of 106 results

IHC-plus™ LOX / Lysyl Oxidase Antibody (aa118-168) LS-B8037
Rabbit Polyclonal to Human LOX / Lysyl Oxidase
Rat, Human
Flo, ICC, IF, IHC, IHC-P, WB
Unconjugated
100µl 1mg/ml  $425.00
Anti-Lysyl Oxidase / LOX antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
LOX propeptide Antibody - Western blot of LOX propeptide on MDA-MB-231.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

LOX / Lysyl Oxidase Antibody (aa118-168, Biotin) LS-C143183
Rabbit Polyclonal to Human LOX / Lysyl Oxidase
Rat, Human
Flo, ICC, IF, IHC, IHC-P, WB
Biotin Conjugated
100µl  $365.00
Anti-Lysyl Oxidase / LOX antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
LOX propeptide Antibody - Western blot of LOX propeptide on MDA-MB-231.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

LOX / Lysyl Oxidase Antibody (aa118-168, DY488) LS-C143185
Rabbit Polyclonal to Human LOX / Lysyl Oxidase
Rat, Human
Flo, ICC, IF, IHC, IHC-P, WB
DY488 Conjugated
100µl  $365.00
Anti-Lysyl Oxidase / LOX antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
LOX propeptide Antibody - Western blot of LOX propeptide on MDA-MB-231.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

IHC-plus™ LOX / Lysyl Oxidase Antibody LS-B9417
Rabbit Polyclonal to Rat LOX / Lysyl Oxidase
Mouse, Rat, Primate, Human
IHC, IHC-P, WB
Unconjugated
100µl  $425.00
Anti-Lysyl Oxidase / LOX antibody IHC staining of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Immunohistochemistry:  LOX Antibody - Staining of LOX in mouse spleen.

LOX / Lysyl Oxidase Antibody (clone OTI9G2) LS-C172331
Mouse Monoclonal [clone OTI9G2] (IgG1) to Human LOX / Lysyl Oxidase
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100µl 1mg/ml  $345.00
IHC of paraffin-embedded Human thyroid tissue using anti-LOX mouse monoclonal antibody.
IHC of paraffin-embedded Carcinoma of Human bladder tissue using anti-LOX mouse monoclonal antibody.

LOX / Lysyl Oxidase Antibody (aa305-320) LS-C148572
Rabbit Polyclonal to Human LOX / Lysyl Oxidase
Rabbit, Mouse, Bat, Human, Monkey
IHC, IHC-Fr, IP, WB
Unconjugated
100µl  $335.00
Western blot of LOX in A) human skin and B) mouse ear skin lysate using Polyclonal Antibody to Lysyl Oxidase (LOX) at 1:500. Goat anti-rabbit Ig HRP secondary antibody, and PicoTect ECL substrate solution, were used for this test.

LOX / Lysyl Oxidase Antibody (aa78-115) LS-C49142
Rabbit Polyclonal to Mouse LOX / Lysyl Oxidase
Mouse, Rat, Pig, Primate, Human
IHC, IHC-P, WB
Unconjugated
100µl 1mg/ml  $335.00
LOX propeptide Antibody - IHC of LOPP in mouse intestine.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Detection of LOPP in MC3T3-E1 cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

LOX / Lysyl Oxidase Antibody (aa300-400) LS-C49028
Rabbit Polyclonal to Human LOX / Lysyl Oxidase
Mouse, Bovine, Rat, Pig, Human
IHC, IHC-P, WB
Unconjugated
50µl 1mg/ml  $335.00
Human placental villi, 40X. Staining of placental trophoblasts using antibody at 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Detection of LOX in mouse kidney lysate using antibody at 1:1000. ECL detection was 15 sec.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

LOX / Lysyl Oxidase Antibody (aa135-155) LS-C143168
Rabbit Polyclonal to Human LOX / Lysyl Oxidase
Mouse, Rat, Human
IHC, WB
Unconjugated
100µl 1mg/ml  $335.00
LOpep4 Antibody - Western blot on cytoplasmic (c) and nuclear (n) extracts of NIH 3T3, ras-transformed (RS 485), PMEF and TGM-1 mouse fibroblast cells.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

LOX / Lysyl Oxidase Antibody (aa213-417) LS-C295235
Rabbit Polyclonal to Human LOX / Lysyl Oxidase
Human
WB
Unconjugated
20µl 0.5mg/ml  $205.00; 100µl 0.5mg/ml  $255.00; 200µl 0.5mg/ml  $305.00; 1ml 0.5mg/ml  $530.00
Western blot of recombinant Lysyl Oxidase / LOX.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western Blot; Sample: Recombinant protein.

LOX / Lysyl Oxidase Antibody (clone OTI8G5) LS-C114933
Publications (1)
Publications (1)
Mouse Monoclonal [clone OTI8G5] (IgG1) to Human LOX / Lysyl Oxidase
Human
IF, IHC, IHC-P, WB
Unconjugated
100µl  $345.00
IHC of paraffin-embedded colon tissue using anti-LOX mouse monoclonal antibody. (Dilution 1:50).
IHC of paraffin-embedded Kidney tissue using anti-LOX mouse monoclonal antibody. (Dilution 1:50).

IHC-plus™ LOX / Lysyl Oxidase Antibody (clone 9A11) LS-B10043
Mouse Monoclonal [clone 9A11] (IgG1) to Human LOX / Lysyl Oxidase
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
50µl  $425.00
Anti-Lysyl Oxidase / LOX antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Anti-LOX mouse monoclonal antibody  immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY LOX.

LOX / Lysyl Oxidase Antibody (clone OTI5C4) LS-C114929
Mouse Monoclonal [clone OTI5C4] (IgG1) to Human LOX / Lysyl Oxidase
Dog, Rat, Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100µl 1mg/ml  $345.00
IHC of paraffin-embedded colon tissue using anti- mouse monoclonal antibody. (Dilution 1:50).
Anti-LOX mouse monoclonal antibody  immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY LOX.

LOX / Lysyl Oxidase Antibody (aa181-196) LS-C71730
Rabbit Polyclonal (IgG) to Rat LOX / Lysyl Oxidase
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
100µl  $530.00

LOX / Lysyl Oxidase Antibody (clone OTI6B7) LS-C114936
Mouse Monoclonal [clone OTI6B7] (IgG1) to Human LOX / Lysyl Oxidase
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100µl 1mg/ml  $345.00
IHC of paraffin-embedded liver tissue using anti-LOX mouse monoclonal antibody. (Dilution 1:50).
IHC of paraffin-embedded Ovary tissue using anti-LOX mouse monoclonal antibody. (Dilution 1:50).

LOX / Lysyl Oxidase Antibody (aa22-168, clone OTI6B7, Carrier-free) LS-C797180
Mouse Monoclonal [clone OTI6B7] (IgG1) to Human LOX / Lysyl Oxidase
Human
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100µg  $395.00
IHC of paraffin-embedded liver tissue using anti-LOX mouse monoclonal antibody. (Dilution 1:50).
IHC of paraffin-embedded Ovary tissue using anti-LOX mouse monoclonal antibody. (Dilution 1:50).

LOX / Lysyl Oxidase Antibody (clone OTI10D11) LS-C172332
Mouse Monoclonal [clone OTI10D11] (IgG1) to Human LOX / Lysyl Oxidase
Human
IF, IHC, IHC-P, WB
Unconjugated
100µl 1mg/ml  $345.00
IHC of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-LOX mouse monoclonal antibody.
IHC of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-LOX mouse monoclonal antibody.

LOX / Lysyl Oxidase Antibody LS-C405432
Rabbit Polyclonal (IgG) to Human LOX / Lysyl Oxidase
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20µl 0.4mg/ml  $205.00; 60µl 0.4mg/ml  $235.00; 120µl 0.4mg/ml  $295.00; 200µl 0.4mg/ml  $395.00
Immunohistochemistry of paraffin-embedded Human colon cancer using LOX Polyclonal Antibody at dilution of 1:25.
Immunohistochemistry of paraffin-embedded Human colon cancer using LOX Polyclonal Antibody at dilution of 1:25.

LOX / Lysyl Oxidase Antibody (aa234-260, Biotin) LS-C520100
Mouse Monoclonal (IgG2b) to Human LOX / Lysyl Oxidase
Human
ELISA, WB
Biotin Conjugated
200µl  $740.00

LOX / Lysyl Oxidase Antibody (clone OTI4E3) LS-C114932
Mouse Monoclonal [clone OTI4E3] (IgG1) to Human LOX / Lysyl Oxidase
Flo, IF, IHC, IHC-P, WB
Unconjugated
100µl 0.42mg/ml  $345.00
Immunohistochemical staining of paraffin-embedded Human Kidney tissue using anti-LOX mouse monoclonal antibody. (Dilution 1:50).
Anti-LOX mouse monoclonal antibody  immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY LOX.

IHC-plus™ LOX / Lysyl Oxidase Antibody LS-B11595
Rabbit Polyclonal (IgG) to Rat LOX / Lysyl Oxidase
Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µg 3mg/ml  $425.00
Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot of Protein-lysine 6-oxidase antibody at 2 ug/ml| with K562 whole cell lysate. Secondary: Goat polyclonal Rabbit IgG at 1:10000 dilution. Predicted band size: 47 KDa. Observed band size: 47 KDa.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

LOX / Lysyl Oxidase Antibody LS-C405433
Rabbit Polyclonal (IgG) to Human LOX / Lysyl Oxidase
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20µl 0.3mg/ml  $205.00; 60µl 0.3mg/ml  $235.00; 120µl 0.3mg/ml  $295.00; 200µl 0.3mg/ml  $395.00
Immunohistochemistry of paraffin-embedded Human lung cancer using LOX Polyclonal Antibody at dilution of 1:30.
Western blot analysis of Human leiomyosarcoma tissue, using LOX Polyclonal Antibody at dilution of 1:400.

LOX / Lysyl Oxidase Antibody (clone OTI9G6) LS-C114937
Mouse Monoclonal [clone OTI9G6] (IgG1) to Human LOX / Lysyl Oxidase
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100µl 1mg/ml  $345.00
IHC of paraffin-embedded colon tissue using anti-LOX mouse monoclonal antibody. (Dilution 1:50).
IHC of paraffin-embedded Kidney tissue using anti-LOX mouse monoclonal antibody. (Dilution 1:50).

LOX / Lysyl Oxidase Antibody (clone OTI6B11) LS-C114935
Mouse Monoclonal [clone OTI6B11] (IgG1) to Human LOX / Lysyl Oxidase
Flo, IF, IHC, IHC-P, WB
Unconjugated
100µl 1mg/ml  $345.00
Immunohistochemical staining of paraffin-embedded endometrium tissue using anti-LOX mouse monoclonal antibody. (Dilution 1:50).
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of breast tissue using anti-LOX mouse monoclonal antibody. (Dilution 1:50).

LOX / Lysyl Oxidase Antibody (aa234-260) LS-C165844
Rabbit Polyclonal to Human LOX / Lysyl Oxidase
Human
Flo, WB
Unconjugated
400µl  $325.00
Western blot of LOX Antibody in MDA-MB468 cell line lysates (35 ug/lane). LOX (arrow) was detected using the purified antibody.
LOX Antibody flow cytometry of 293 cells (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Showing 1-25 of 106 results

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).